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    The context of gene expression regulation

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    Authors
    Gibcus, Johan H.
    Dekker, Job
    UMass Chan Affiliations
    Program in Gene Function and Expression
    Program in Systems Biology
    Document Type
    Journal Article
    Publication Date
    2012-04-08
    Keywords
    Gene Expression Regulation
    Genetics and Genomics
    
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    Abstract
    Recent advances in sequencing technologies have uncovered a world of RNAs that do not code for proteins, known as non-protein coding RNAs, that play important roles in gene regulation. Along with histone modifications and transcription factors, non-coding RNA is part of a layer of transcriptional control on top of the DNA code. This layer of components and their interactions specifically enables (or disables) the modulation of three-dimensional folding of chromatin to create a context for transcriptional regulation that underlies cell-specific transcription. In this perspective, we propose a structural and functional hierarchy, in which the DNA code, proteins and non-coding RNAs act as context creators to fold chromosomes and regulate genes.
    Source

    F1000 Biology Reports 2012, 4:8 (doi:10.3410/B4-8). Link to article on publisher's website

    DOI
    10.3410/B4-8
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43978
    PubMed ID
    22500194
    Related Resources
    Link to article in PubMed
    Rights

    This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/legalcode), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes.

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    10.3410/B4-8
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