Abstract
Recent advances in sequencing technologies have uncovered a world of RNAs that do not code for proteins, known as non-protein coding RNAs, that play important roles in gene regulation. Along with histone modifications and transcription factors, non-coding RNA is part of a layer of transcriptional control on top of the DNA code. This layer of components and their interactions specifically enables (or disables) the modulation of three-dimensional folding of chromatin to create a context for transcriptional regulation that underlies cell-specific transcription. In this perspective, we propose a structural and functional hierarchy, in which the DNA code, proteins and non-coding RNAs act as context creators to fold chromosomes and regulate genes.Source
F1000 Biology Reports 2012, 4:8 (doi:10.3410/B4-8). Link to article on publisher's website
DOI
10.3410/B4-8Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43978PubMed ID
22500194Related Resources
Link to article in PubMedRights
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/legalcode), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes.
ae974a485f413a2113503eed53cd6c53
10.3410/B4-8