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    Evidence for dynamically organized modularity in the yeast protein-protein interaction network

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    Authors
    Han, Jing-Dong J.
    Bertin, Nicolas
    Hao, Tong
    Goldberg, Debra S.
    Berriz, Gabriel F.
    Zhang, Lan V.
    Dupuy, Denis
    Walhout, Albertha J. M.
    Cusick, Michael E.
    Roth, Frederick P.
    Vidal, Marc
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    UMass Chan Affiliations
    Program in Molecular Medicine
    Program in Gene Function and Expression
    Document Type
    Journal Article
    Publication Date
    2004-06-11
    Keywords
    Computer Simulation
    Fungal Proteins
    Genes, Fungal
    *Models, Biological
    Protein Binding
    Yeasts
    Genetics and Genomics
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1038/nature02555
    Abstract
    In apparently scale-free protein-protein interaction networks, or 'interactome' networks, most proteins interact with few partners, whereas a small but significant proportion of proteins, the 'hubs', interact with many partners. Both biological and non-biological scale-free networks are particularly resistant to random node removal but are extremely sensitive to the targeted removal of hubs. A link between the potential scale-free topology of interactome networks and genetic robustness seems to exist, because knockouts of yeast genes encoding hubs are approximately threefold more likely to confer lethality than those of non-hubs. Here we investigate how hubs might contribute to robustness and other cellular properties for protein-protein interactions dynamically regulated both in time and in space. We uncovered two types of hub: 'party' hubs, which interact with most of their partners simultaneously, and 'date' hubs, which bind their different partners at different times or locations. Both in silico studies of network connectivity and genetic interactions described in vivo support a model of organized modularity in which date hubs organize the proteome, connecting biological processes--or modules--to each other, whereas party hubs function inside modules.
    Source
    Nature. 2004 Jul 1;430(6995):88-93. Epub 2004 Jun 9. Link to article on publisher's site
    DOI
    10.1038/nature02555
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43979
    PubMed ID
    15190252; 15190252
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/nature02555
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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