CTCF and cohesin help neurons raise their self-awareness
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Program in Gene Function and Expression
Document Type
Journal ArticlePublication Date
2012-06-05Keywords
Repressor ProteinsDNA-Binding Proteins
Chromosomal Proteins, Non-Histone
Neurons
Gene Expression Regulation
Genetics and Genomics
Metadata
Show full item recordAbstract
In the brain neurons form extensively intermingled projections and synaptic interactions between them. To achieve proper neural connectivity, interactions between sections belonging to the same neuron are avoided. However, how can a cell tell, when it encounters another neuronal projection, whether it is part of the same cell? In other words, how do neurons become self-aware?Source
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8799-800. Epub 2012 May 21. Link to article on publisher's site
DOI
10.1073/pnas.1206195109Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43982PubMed ID
22615386Related Resources
Link to Article in PubMedRights
Publisher PDF posted as allowed by the publisher's author rights policy at http://www.pnas.org/site/misc/authorfaq.shtml.