The interplay between transcription factors and microRNAs in genome-scale regulatory networks
Document Type
Journal ArticlePublication Date
2009-03-11Keywords
AnimalsGene Regulatory Networks
Genome
Humans
MicroRNAs
Transcription Factors
Genetics and Genomics
Metadata
Show full item recordAbstract
Metazoan genomes contain thousands of protein-coding and non-coding RNA genes, most of which are differentially expressed, i.e., at different locations, at different times during development, or in response to environmental signals. Differential gene expression is achieved through complex regulatory networks that are controlled in part by two types of trans-regulators: transcription factors (TFs) and microRNAs (miRNAs). TFs bind to cis-regulatory DNA elements that are often located in or near their target genes, while miRNAs hybridize to cis-regulatory RNA elements mostly located in the 3' untranslated region of their target mRNAs. Here, we describe how these trans-regulators interact with each other in the context of gene regulatory networks to coordinate gene expression at the genome-scale level, and discuss future challenges of integrating these networks with other types of functional networks.Source
Bioessays. 2009 Apr;31(4):435-45. Link to article on publisher's siteDOI
10.1002/bies.200800212Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44052PubMed ID
19274664; 19274664Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/bies.200800212