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    The interplay between transcription factors and microRNAs in genome-scale regulatory networks

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    Authors
    Martinez, Natalia Julia
    Walhout, Albertha J. M.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Program in Gene Function and Expression
    Document Type
    Journal Article
    Publication Date
    2009-03-11
    Keywords
    Animals
    Gene Regulatory Networks
    Genome
    Humans
    MicroRNAs
    Transcription Factors
    Genetics and Genomics
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1002/bies.200800212
    Abstract
    Metazoan genomes contain thousands of protein-coding and non-coding RNA genes, most of which are differentially expressed, i.e., at different locations, at different times during development, or in response to environmental signals. Differential gene expression is achieved through complex regulatory networks that are controlled in part by two types of trans-regulators: transcription factors (TFs) and microRNAs (miRNAs). TFs bind to cis-regulatory DNA elements that are often located in or near their target genes, while miRNAs hybridize to cis-regulatory RNA elements mostly located in the 3' untranslated region of their target mRNAs. Here, we describe how these trans-regulators interact with each other in the context of gene regulatory networks to coordinate gene expression at the genome-scale level, and discuss future challenges of integrating these networks with other types of functional networks.
    Source
    Bioessays. 2009 Apr;31(4):435-45. Link to article on publisher's site
    DOI
    10.1002/bies.200800212
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44052
    PubMed ID
    19274664; 19274664
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/bies.200800212
    Scopus Count
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