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dc.contributor.authorMartinez, Natalia Julia
dc.contributor.authorWalhout, Albertha J. M.
dc.date2022-08-11T08:10:15.000
dc.date.accessioned2022-08-23T17:01:39Z
dc.date.available2022-08-23T17:01:39Z
dc.date.issued2009-03-11
dc.date.submitted2009-11-23
dc.identifier.citationBioessays. 2009 Apr;31(4):435-45. <a href="http://dx.doi.org/10.1002/bies.200800212">Link to article on publisher's site</a>
dc.identifier.issn1521-1878 (Electronic)
dc.identifier.doi10.1002/bies.200800212
dc.identifier.pmid19274664
dc.identifier.pmid19274664
dc.identifier.urihttp://hdl.handle.net/20.500.14038/44052
dc.description.abstractMetazoan genomes contain thousands of protein-coding and non-coding RNA genes, most of which are differentially expressed, i.e., at different locations, at different times during development, or in response to environmental signals. Differential gene expression is achieved through complex regulatory networks that are controlled in part by two types of trans-regulators: transcription factors (TFs) and microRNAs (miRNAs). TFs bind to cis-regulatory DNA elements that are often located in or near their target genes, while miRNAs hybridize to cis-regulatory RNA elements mostly located in the 3' untranslated region of their target mRNAs. Here, we describe how these trans-regulators interact with each other in the context of gene regulatory networks to coordinate gene expression at the genome-scale level, and discuss future challenges of integrating these networks with other types of functional networks.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=19274664&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/bies.200800212
dc.subjectAnimals
dc.subjectGene Regulatory Networks
dc.subjectGenome
dc.subjectHumans
dc.subjectMicroRNAs
dc.subjectTranscription Factors
dc.subjectGenetics and Genomics
dc.titleThe interplay between transcription factors and microRNAs in genome-scale regulatory networks
dc.typeJournal Article
dc.source.journaltitleBioEssays : news and reviews in molecular, cellular and developmental biology
dc.source.volume31
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/pgfe_pp/28
dc.identifier.contextkey1070851
html.description.abstract<p>Metazoan genomes contain thousands of protein-coding and non-coding RNA genes, most of which are differentially expressed, i.e., at different locations, at different times during development, or in response to environmental signals. Differential gene expression is achieved through complex regulatory networks that are controlled in part by two types of trans-regulators: transcription factors (TFs) and microRNAs (miRNAs). TFs bind to cis-regulatory DNA elements that are often located in or near their target genes, while miRNAs hybridize to cis-regulatory RNA elements mostly located in the 3' untranslated region of their target mRNAs. Here, we describe how these trans-regulators interact with each other in the context of gene regulatory networks to coordinate gene expression at the genome-scale level, and discuss future challenges of integrating these networks with other types of functional networks.</p>
dc.identifier.submissionpathpgfe_pp/28
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentProgram in Gene Function and Expression
dc.source.pages435-45


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