• Login
    View Item 
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    ars.2010.3490.pdf
    Size:
    407.3Kb
    Format:
    PDF
    Download
    Authors
    Yen, Kelvin
    Narasimhan, Sri Devi
    Tissenbaum, Heidi A.
    UMass Chan Affiliations
    Program in Gene Function and Expression
    Document Type
    Journal Article
    Publication Date
    2011-02-15
    Keywords
    Caenorhabditis elegans Proteins
    Transcription Factors
    Forkhead Transcription Factors
    Insulin-Like Growth Factor I
    Receptor, IGF Type 1
    Genetics and Genomics
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1089/ars.2010.3490
    Abstract
    The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately downregulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes.
    Source
    Antioxid Redox Signal. 2011 Feb 15;14(4):623-34. Epub 2010 Nov 30. Link to article on publisher's site
    DOI
    10.1089/ars.2010.3490
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44059
    PubMed ID
    20673162
    Related Resources
    Link to Article in PubMed
    Rights

    This is a copy of an article published in Antioxidants & Redox Signaling © 2010 Mary Ann Liebert, Inc. and available online at: http://www.liebertonline.com.

    ae974a485f413a2113503eed53cd6c53
    10.1089/ars.2010.3490
    Scopus Count
    Collections
    UMass Chan Faculty and Researcher Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.