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    Chromatin as a potential carrier of heritable information

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    Authors
    Kaufman, Paul D.
    Rando, Oliver J.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Program in Gene Function and Expression
    Document Type
    Journal Article
    Publication Date
    2010-03-20
    Keywords
    Animals
    Chromatin
    Epigenesis, Genetic
    Humans
    Inheritance Patterns
    Models, Genetic
    Time Factors
    Genetics and Genomics
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.ceb.2010.02.002
    Abstract
    Organisms with the same genome can inherit information in addition to that encoded in the DNA sequence-this is known as epigenetic inheritance. Epigenetic inheritance is responsible for many of the phenotypic differences between different cell types in multicellular organisms. Work by many investigators over the past decades has suggested that a great deal of epigenetic information might be carried in the pattern of post-translational modifications of the histone proteins, although this is not as well established as many believe. For example, it is unclear whether and how the histones, which are displaced from the chromosome during passage of the replication fork and are often exchanged from the DNA template at other times, carry information from one cellular generation to the next. Here, we briefly review the evidence that some chromatin states are indeed heritable, and then focus on the mechanistic challenges that remain in order to understand how this inheritance can be achieved.
    Source
    Curr Opin Cell Biol. 2010 Jun;22(3):284-90. Epub 2010 Mar 17. Link to article on publisher's site
    DOI
    10.1016/j.ceb.2010.02.002
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44084
    PubMed ID
    20299197
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ceb.2010.02.002
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