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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Gene Function and Expression
Document Type
Journal ArticlePublication Date
2010-03-20Keywords
AnimalsChromatin
Epigenesis, Genetic
Humans
Inheritance Patterns
Models, Genetic
Time Factors
Genetics and Genomics
Metadata
Show full item recordAbstract
Organisms with the same genome can inherit information in addition to that encoded in the DNA sequence-this is known as epigenetic inheritance. Epigenetic inheritance is responsible for many of the phenotypic differences between different cell types in multicellular organisms. Work by many investigators over the past decades has suggested that a great deal of epigenetic information might be carried in the pattern of post-translational modifications of the histone proteins, although this is not as well established as many believe. For example, it is unclear whether and how the histones, which are displaced from the chromosome during passage of the replication fork and are often exchanged from the DNA template at other times, carry information from one cellular generation to the next. Here, we briefly review the evidence that some chromatin states are indeed heritable, and then focus on the mechanistic challenges that remain in order to understand how this inheritance can be achieved.Source
Curr Opin Cell Biol. 2010 Jun;22(3):284-90. Epub 2010 Mar 17. Link to article on publisher's siteDOI
10.1016/j.ceb.2010.02.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44084PubMed ID
20299197Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ceb.2010.02.002