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    Lack of oscillations in cyclic AMP, cAMP-protein kinase and glycogen phosphorylase during the cardiac cycle in perfused rat hearts

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    Authors
    George, E. E.
    Dobson, James G. Jr.
    UMass Chan Affiliations
    Department of Physiology
    Document Type
    Journal Article
    Publication Date
    1992-05-01
    Keywords
    Animals
    Cyclic AMP
    Diastole
    Male
    Myocardial Contraction
    Myocardium
    Perfusion
    Phosphorylases
    Protein Kinases
    Rats
    Rats, Inbred Strains
    Systole
    Cardiovascular Diseases
    Cellular and Molecular Physiology
    Physiology
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    Link to Full Text
    http://dx.doi.org/10.1016/0022-2828(92)91837-U
    Abstract
    It is unclear whether reported fluctuations in the level of adenosine 3',5'-cyclic monophosphate (cAMP) during a single cardiac cycle in ventricular muscle are associated with distal changes in cAMP-dependent processes. The degree of cAMP variation and its effect, if any, on biochemical sequelae during the cardiac cycle, were investigated by determining the level of cAMP and the activity ratios of cAMP-dependent protein kinase and glycogen phosphorylase in the rat ventricular myocardium. Isolated perfused hearts contracting at 240 beats/min and free of exogenously administered catecholamines were freeze-clamped, utilizing an automated clamping device capable of freezing the entire heart in less than 50 ms. The cardiac cycle was segmented into phases utilizing three different segmentation schemes. No significant difference was detected between phases regardless of the method of segmentation for cAMP, cAMP-dependent protein kinase, or glycogen phosphorylase levels. These results suggest that the levels of cAMP and the activities of cAMP-dependent protein kinase and glycogen phosphorylase do not vary significantly during a single cardiac cycle in the mammalian myocardium.
    Source
    J Mol Cell Cardiol. 1992 May;24(5):477-84.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44166
    PubMed ID
    1321913
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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