TRAPPing a Rab GTPase by the Tail
Name:
Publisher version
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Molecular Medicine
Document Type
Journal ArticlePublication Date
2019-01-07Keywords
Amino Acids, Peptides, and ProteinsBiochemistry
Cell and Developmental Biology
Cells
Enzymes and Coenzymes
Molecular Biology
Molecular Genetics
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Show full item recordAbstract
GEFs play a key role in activation and membrane targeting of Rab GTPases. In this issue of Developmental Cell, Thomas et al. (2018) demonstrate how two TRAPP complexes with a common GEF core select distinct Rab substrates through a steric gating mechanism involving their hypervariable tails.Source
Dev Cell. 2019 Jan 7;48(1):9-11. doi: 10.1016/j.devcel.2018.12.008. Link to article on publisher's site