Authors
Sztul, ElizabethChen, Pei-Wen
Casanova, James E.
Cherfils, Jacqueline
Dacks, Joel B.
Lambright, David G.
Lee, Fang-Jen S.
Randazzo, Paul A.
Santy, Lorraine C.
Schurmann, Annette
Wilhelmi, Ilka
Yohe, Marielle E.
Kahn, Richard A.
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2019-05-15Keywords
cell biologyprotein families
ARF GTPases
ARF GEFs
ARF GAPs
cell signaling
Amino Acids, Peptides, and Proteins
Biochemistry
Cell Biology
Cells
Enzymes and Coenzymes
Molecular Biology
Nucleic Acids, Nucleotides, and Nucleosides
Metadata
Show full item recordAbstract
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a protein family in the aggregate yields additional information, as one can include analyses of their coevolution, acquisition or loss of functionalities, structural pliability, and the emergence of shared or variations in molecular mechanisms. An even richer understanding of cell biology can be achieved through evaluating functionally linked protein families. In this review, we summarize current knowledge of three protein families: the ARF GTPases, the guanine nucleotide exchange factors (ARF GEFs) that activate them, and the GTPase-activating proteins (ARF GAPs) that have the ability to both propagate and terminate signaling. However, despite decades of scrutiny, our understanding of how these essential proteins function in cells remains fragmentary. We believe that the inherent complexity of ARF signaling and its regulation by GEFs and GAPs will require the concerted effort of many laboratories working together, ideally within a consortium to optimally pool information and resources. The collaborative study of these three functionally connected families ( > /=70 mammalian genes) will yield transformative insights into regulation of cell signaling.Source
Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820. Link to article on publisher's site
DOI
10.1091/mbc.E18-12-0820Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44385PubMed ID
31084567Related Resources
Rights
© 2019 Sztul et al. Publisher PDF posted as allowed by the publisher's author rights policy at https://www.molbiolcell.org/info-for-authors#license. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).Distribution License
http://creativecommons.org/licenses/by-nc-sa/3.0/ae974a485f413a2113503eed53cd6c53
10.1091/mbc.E18-12-0820
Scopus Count
Collections
Except where otherwise noted, this item's license is described as © 2019 Sztul et al. Publisher PDF posted as allowed by the publisher's author rights policy at https://www.molbiolcell.org/info-for-authors#license. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).