UMass Chan AffiliationsProgram in Molecular Medicine
Document TypeJournal Article
host–pathogen arms race
Biochemistry, Biophysics, and Structural Biology
Ecology and Evolutionary Biology
Genetics and Genomics
MetadataShow full item record
AbstractTransposons are major genome constituents that can mobilize and trigger mutations, DNA breaks and chromosome rearrangements. Transposon silencing is particularly important in the germline, which is dedicated to transmission of the inherited genome. Piwi-interacting RNAs (piRNAs) guide a host defence system that transcriptionally and post-transcriptionally silences transposons during germline development. While germline control of transposons by the piRNA pathway is conserved, many piRNA pathway genes are evolving rapidly under positive selection, and the piRNA biogenesis machinery shows remarkable phylogenetic diversity. Conservation of core function combined with rapid gene evolution is characteristic of a host-pathogen arms race, suggesting that transposons and the piRNA pathway are engaged in an evolutionary tug of war that is driving divergence of the biogenesis machinery. Recent studies suggest that this process may produce biochemical incompatibilities that contribute to reproductive isolation and species divergence.
Open Biol. 2019 Jan 31;9(1):180181. doi: 10.1098/rsob.180181. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/44390
RightsCopyright 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.