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    Inductive asymmetric cell division: The WRM leads the way

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    Authors
    Ishidate, Takao
    Kim, Soyoung
    Mello, Craig C.
    Shirayama, Masaki
    UMass Chan Affiliations
    Program in Molecular Medicine
    RNA Therapeutics Institute
    Document Type
    Journal Article
    Publication Date
    2013-10-01
    Keywords
    Asymmetric Cell Division
    Biochemistry
    Cell Biology
    Cellular and Molecular Physiology
    Genetic Processes
    Molecular Biology
    Molecular Genetics
    
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    Abstract
    C. elegans, with its invariant cell lineage, provides a powerful model system in which to study signaling-dependent asymmetric cell division. The C. elegans β-catenin-related protein, WRM-1, specifies endoderm at the 4-cell stage during the first cell signaling-induced asymmetric cell division of embryogenesis. During this interaction, Wnt signaling and the cell cycle regulator CDK-1 act together to induce the asymmetric cortical release of WRM-1 at prophase of the EMS cell cycle. Genetic studies suggest that release of WRM-1 unmasks a cortical site that drives EMS spindle rotation onto the polarized axis of the cell, simultaneously making WRM-1 available for nuclear translocation, and downstream signaling to specify endoderm. These studies suggest a general paradigm for how cortical factors like WRM-1 can function at the cell cortex to mask potentially confounding polarity cues, and when released with appropriate cell cycle timing, can also function downstream to define cell fate.
    Source

    Ishidate T, Kim S, Mello CC, Shirayama M. Inductive asymmetric cell division: The WRM leads the way. Worm 2013; 2:e26276; http://dx.doi.org/10.4161/worm.26276

    DOI
    10.4161/worm.26276
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44416
    PubMed ID
    24524013
    Related Resources
    Link to article in PubMed
    Rights

    This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

    ae974a485f413a2113503eed53cd6c53
    10.4161/worm.26276
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