UMass Chan AffiliationsProgram in Molecular Medicine
RNA Therapeutics Institute
Document TypeJournal Article
KeywordsAsymmetric Cell Division
Cellular and Molecular Physiology
MetadataShow full item record
AbstractC. elegans, with its invariant cell lineage, provides a powerful model system in which to study signaling-dependent asymmetric cell division. The C. elegans β-catenin-related protein, WRM-1, specifies endoderm at the 4-cell stage during the first cell signaling-induced asymmetric cell division of embryogenesis. During this interaction, Wnt signaling and the cell cycle regulator CDK-1 act together to induce the asymmetric cortical release of WRM-1 at prophase of the EMS cell cycle. Genetic studies suggest that release of WRM-1 unmasks a cortical site that drives EMS spindle rotation onto the polarized axis of the cell, simultaneously making WRM-1 available for nuclear translocation, and downstream signaling to specify endoderm. These studies suggest a general paradigm for how cortical factors like WRM-1 can function at the cell cortex to mask potentially confounding polarity cues, and when released with appropriate cell cycle timing, can also function downstream to define cell fate.
Ishidate T, Kim S, Mello CC, Shirayama M. Inductive asymmetric cell division: The WRM leads the way. Worm 2013; 2:e26276; http://dx.doi.org/10.4161/worm.26276
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/44416
Related ResourcesLink to article in PubMed
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