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    Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

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    Authors
    Ward, Jeanine
    Kanchagar, Chitra
    Veksler-Lublinsky, Isana
    Lee, Rosalind C.
    McGill, Mitchell R.
    Jaeschke, Hartmut
    Curry, Steven C.
    Ambros, Victor R.
    UMass Chan Affiliations
    Department of Medicine
    RNA Therapeutics Institute
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2014-08-19
    Keywords
    Acetaminophen
    Acetylcysteine
    Alanine Transaminase
    Hepatitis
    Humans
    Ischemia
    MicroRNAs
    Poisoning
    Real-Time Polymerase Chain Reaction
    Biochemistry
    Digestive System Diseases
    Hepatology
    Molecular Biology
    Molecular Genetics
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143020/
    Abstract
    We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated in the plasma or serum of acetaminophen (APAP) overdose patients. Most of these circulating microRNAs decrease toward normal levels during treatment with N-acetyl cysteine (NAC). We identified a set of 11 miRNAs whose profiles and dynamics in the circulation during NAC treatment can discriminate APAP hepatotoxicity from ischemic hepatitis. The elevation of certain miRNAs can precede the dramatic rise in the standard biomarker, alanine aminotransferase (ALT), and these miRNAs also respond more rapidly than ALT to successful treatment. Our results suggest that miRNAs can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.
    Source
    Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12169-74. doi: 10.1073/pnas.1412608111. Epub 2014 Aug 4. Link to article on publisher's site
    DOI
    10.1073/pnas.1412608111
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44425
    PubMed ID
    25092309
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1412608111
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