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Authors
Ambros, Victor R.UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2011-08-01Keywords
AnimalsCaenorhabditis elegans
Cell Differentiation
Cell Lineage
*Gene Expression Regulation, Developmental
Humans
MicroRNAs
Developmental Biology
Molecular Biology
Molecular Genetics
Metadata
Show full item recordAbstract
MicroRNAs regulate temporal transitions in gene expression associated with cell fate progression and differentiation throughout animal development. Genetic analysis of developmental timing in the nematode Caenorhabditis elegans identified two evolutionarily conserved microRNAs, lin-4/mir-125 and let-7, that regulate cell fate progression and differentiation in C. elegans cell lineages. MicroRNAs perform analogous developmental timing functions in other animals, including mammals. By regulating cell fate choices and transitions between pluripotency and differentiation, microRNAs help to orchestrate developmental events throughout the developing animal, and to play tissue homeostasis roles important for disease, including cancer.Source
Curr Opin Genet Dev. 2011 Aug;21(4):511-7. doi: 10.1016/j.gde.2011.04.003. Epub 2011 Apr 29. Link to article on publisher's site
DOI
10.1016/j.gde.2011.04.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44435PubMed ID
21530229Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.gde.2011.04.003