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    The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans

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    Authors
    Karp, Xantha
    Ambros, Victor R.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2011-01-01
    Keywords
    Animals
    Caenorhabditis elegans
    Caenorhabditis elegans Proteins
    Cytochrome P-450 Enzyme System
    DNA-Binding Proteins
    Insulin
    Larva
    Signal Transduction
    Time Factors
    Transcription Factors
    Transforming Growth Factor beta
    Biochemistry
    Developmental Biology
    Molecular Biology
    Molecular Genetics
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018311/
    Abstract
    Animals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.
    Source

    Genetics. 2011 Jan;187(1):345-53. doi: 10.1534/genetics.110.123992. Epub 2010 Oct 26. Link to article on publisher's site

    DOI
    10.1534/genetics.110.123992
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44438
    PubMed ID
    20980238
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1534/genetics.110.123992
    Scopus Count
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