The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans
Ambros, Victor R.
UMass Chan AffiliationsProgram in Molecular Medicine
Document TypeJournal Article
Caenorhabditis elegans Proteins
Cytochrome P-450 Enzyme System
Transforming Growth Factor beta
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AbstractAnimals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.
Genetics. 2011 Jan;187(1):345-53. doi: 10.1534/genetics.110.123992. Epub 2010 Oct 26. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/44438
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