The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2011-01-01Keywords
AnimalsCaenorhabditis elegans
Caenorhabditis elegans Proteins
Cytochrome P-450 Enzyme System
DNA-Binding Proteins
Insulin
Larva
Signal Transduction
Time Factors
Transcription Factors
Transforming Growth Factor beta
Biochemistry
Developmental Biology
Molecular Biology
Molecular Genetics
Metadata
Show full item recordAbstract
Animals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.Source
Genetics. 2011 Jan;187(1):345-53. doi: 10.1534/genetics.110.123992. Epub 2010 Oct 26. Link to article on publisher's site
DOI
10.1534/genetics.110.123992Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44438PubMed ID
20980238Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1534/genetics.110.123992