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    Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver

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    Authors
    Dumas, Sabrina N.
    Guo, Chang-An
    Kim, Jason K.
    Friedline, Randall H.
    Ntambi, James M.
    UMass Chan Affiliations
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2019-01-01
    Keywords
    Adipose
    Diabetes
    Fat
    Gluconeogenesis
    Glucose
    IL6
    Inflammation
    Lipids
    Liver
    Metabolism
    Obesity
    SCD1
    Skin
    Steatosis
    Amino Acids, Peptides, and Proteins
    Biochemical Phenomena, Metabolism, and Nutrition
    Biochemistry, Biophysics, and Structural Biology
    Enzymes and Coenzymes
    Lipids
    Physiology
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    Link to Full Text
    https://doi.org/10.1016/j.bbrc.2018.11.083
    Abstract
    Stearoyl-CoA desaturase 1 (SCD1), a lipogenic enzyme that adds a double bond at the delta 9 position of stearate (C18: 0) and palmitate (C16: 0), has been proven to be important in the development of obesity. Mice with skin-specific deficiency of SCD1 (SKO) display increased whole-body energy expenditure, which is protective against adiposity from a high-fat diet because it improves glucose clearance, insulin sensitivity, and hepatic steatosis. Of note, these mice also display elevated levels of the "pro-inflammatory" plasma interleukin-6 (IL-6). In whole skin of SKO mice, IL-6 mRNA levels are increased, and protein expression is evident in hair follicle cells and in keratinocytes. Recently, the well-known role of IL-6 in causing white adipose tissue lipolysis has been linked to indirectly activating the gluconeogenic enzyme pyruvate carboxylase 1 in the liver, thereby increasing hepatic glucose production. In this study, we suggest that skin-derived IL-6 leads to white adipose tissue lipolysis, which contributes to the lean phenotype of SKO mice without the incidence of meta-inflammation that is associated with IL-6 signaling.
    Source

    Biochem Biophys Res Commun. 2019 Jan 1;508(1):87-91. doi: 10.1016/j.bbrc.2018.11.083. Epub 2018 Nov 22. Link to article on publisher's site

    DOI
    10.1016/j.bbrc.2018.11.083
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44496
    PubMed ID
    30470572
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbrc.2018.11.083
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