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dc.contributor.authorMcTigue, Kathleen M.
dc.contributor.authorChang, Yue-Fang
dc.contributor.authorEaton, Charles B.
dc.contributor.authorGarcia, Lorena
dc.contributor.authorJohnson, Karen C.
dc.contributor.authorLewis, Cora E.
dc.contributor.authorLiu, Simin
dc.contributor.authorMackey, Rachel H.
dc.contributor.authorRobinson, Jennifer
dc.contributor.authorRosal, Milagros C
dc.contributor.authorSnetselaar, Linda G.
dc.contributor.authorValoski, Alice
dc.contributor.authorKuller, Lewis H.
dc.date2022-08-11T08:10:19.000
dc.date.accessioned2022-08-23T17:04:09Z
dc.date.available2022-08-23T17:04:09Z
dc.date.issued2014-02-03
dc.date.submitted2014-02-26
dc.identifier.citationMcTigue KM, Chang YF, Eaton C, Garcia L, Johnson KC, Lewis CE, Liu S, Mackey RH, Robinson J, Rosal MC, Snetselaar L, Valoski A, Kuller LH. Severe obesity, heart disease, and death among white, african american, and hispanic postmenopausal women. Obesity (Silver Spring). 2012 Dec 12. doi:10.1002/oby.20224. <a href="http://dx.doi.org/10.1002/oby.20224" target="_blank"> Link to article on publisher's site</a>
dc.identifier.issn1930-7381 (Linking)
dc.identifier.doi10.1002/oby.20224
dc.identifier.pmid24493096
dc.identifier.urihttp://hdl.handle.net/20.500.14038/44577
dc.description.abstractOBJECTIVE: To compare mortality, nonfatal coronary heart disease (CHD), and congestive heart failure (CHF) risk across BMI categories in white, African American, and Hispanic women, with a focus on severe obesity (BMI >/= 40), and examine heterogeneity in weight-related CHD risk. DESIGN AND METHODS: Among 156,775 Women's Health Initiative observational study and clinical trial participants (September 1993-12 September 2005), multivariable Cox models estimated relative risk for mortality, CHD, and CHF. CHD incidence was calculated by anthropometry, race, and cardiovascular risk factors (CVRF). RESULTS: Mortality, nonfatal CHD, and CHF incidence generally rose with BMI category. For severe obesity versus normal BMI, hazard ratios (HRs, 95% confidence interval) for mortality were 1.97 (1.77-2.20) in white, 1.55 (1.20-2.00) in African American, and 2.59 (1.55-4.31) in Hispanic women; for CHD, HRs were 2.05 (1.80-2.35), 2.24 (1.57-3.19), and 2.95 (1.60-5.41) respectively; for CHF, HRs were 5.01 (4.33-5.80), 3.60 (2.30-5.62), and 6.05 (2.49-14.69). CVRF variation resulted in substantial variation in CHD rates across BMI categories, even in severe obesity. CHD incidence was similar by race/ethnicity when differences in BMI or CVRF were accounted for. CONCLUSIONS: Severe obesity increases mortality, nonfatal CHD, and CHF risk in women of diverse race/ethnicity. CVRF heterogeneity contributes to variation in CHD incidence even in severe obesity.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24493096&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/oby.20224
dc.subjectcardiovascular diseases/epidemiology
dc.subjectcardiovascular diseases/etiology
dc.subjectlongitudinal studies
dc.subjectobesity
dc.subjectmorbid/complications
dc.subjectobesity
dc.subjectmorbid/epidemiology
dc.subjectobesity/epidemiology
dc.subjectobesity/complications
dc.subjectBehavior and Behavior Mechanisms
dc.subjectClinical Epidemiology
dc.subjectCommunity Health
dc.subjectCommunity Health and Preventive Medicine
dc.subjectPublic Health
dc.subjectWomen's Health
dc.titleSevere obesity, heart disease, and death among white, african american, and hispanic postmenopausal women
dc.typeJournal Article
dc.source.journaltitleObesity (Silver Spring, Md.)
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/prc_pubs/17
dc.identifier.contextkey5214573
html.description.abstract<p>OBJECTIVE: To compare mortality, nonfatal coronary heart disease (CHD), and congestive heart failure (CHF) risk across BMI categories in white, African American, and Hispanic women, with a focus on severe obesity (BMI >/= 40), and examine heterogeneity in weight-related CHD risk.</p> <p>DESIGN AND METHODS: Among 156,775 Women's Health Initiative observational study and clinical trial participants (September 1993-12 September 2005), multivariable Cox models estimated relative risk for mortality, CHD, and CHF. CHD incidence was calculated by anthropometry, race, and cardiovascular risk factors (CVRF).</p> <p>RESULTS: Mortality, nonfatal CHD, and CHF incidence generally rose with BMI category. For severe obesity versus normal BMI, hazard ratios (HRs, 95% confidence interval) for mortality were 1.97 (1.77-2.20) in white, 1.55 (1.20-2.00) in African American, and 2.59 (1.55-4.31) in Hispanic women; for CHD, HRs were 2.05 (1.80-2.35), 2.24 (1.57-3.19), and 2.95 (1.60-5.41) respectively; for CHF, HRs were 5.01 (4.33-5.80), 3.60 (2.30-5.62), and 6.05 (2.49-14.69). CVRF variation resulted in substantial variation in CHD rates across BMI categories, even in severe obesity. CHD incidence was similar by race/ethnicity when differences in BMI or CVRF were accounted for.</p> <p>CONCLUSIONS: Severe obesity increases mortality, nonfatal CHD, and CHF risk in women of diverse race/ethnicity. CVRF heterogeneity contributes to variation in CHD incidence even in severe obesity.</p>
dc.identifier.submissionpathprc_pubs/17
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine


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