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    Diet quality and survival after ovarian cancer: results from the Women's Health Initiative

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    Authors
    Thomson, Cynthia A.
    E Crane, Tracy
    Wertheim, Betsy C.
    Neuhouser, Marian L.
    Li, Wenjun
    Snetselaar, Linda G.
    Basen-Engquist, Karen M.
    Zhou, Yang
    Irwin, Melinda L.
    UMass Chan Affiliations
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Prevention Research Center
    Document Type
    Journal Article
    Publication Date
    2014-10-21
    Keywords
    Dietetics and Clinical Nutrition
    Neoplasms
    Women's Health
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271032/
    Abstract
    BACKGROUND: Survival after an ovarian cancer diagnosis is poor. Given the high mortality in these patients, efforts to identify modifiable lifestyle behaviors that could influence survival are needed. Earlier evidence suggests a protective role for vegetables, but no prior studies have evaluated overall dietary quality and ovarian cancer survival. The purpose of this analysis was to evaluate the role of prediagnosis diet quality in ovarian cancer survival. METHODS: We identified 636 centrally adjudicated cases of ovarian cancer within the Women's Health Initiative Observational Study or Clinical Trials of 161808 postmenopausal women followed from 1995 to 2012. Dietary quality was assessed for the Healthy Eating Index (2005) using a food frequency questionnaire, covariables were obtained from standardized questionnaires, and adiposity was measured by clinic-based measurements of height, weight, and waist circumference. The association between diet quality and mortality was analyzed using Cox proportional hazards regression, adjusted for potential confounders, and stratified by waist circumference, physical activity level, and diabetes status. Tests of statistical significance were two-sided. RESULTS: Overall, higher diet quality was associated with lower all-cause mortality after ovarian cancer (hazard ratio [HR] for highest vs lowest tertile = 0.73; 95% confidence interval [CI] = 0.55 to 0.97, P(trend) = .03). The effect was strongest among women with waist circumference of 88 cm or less and with no history of diabetes (HR = 0.73, 95% CI = 0.54 to 0.98). Physical activity level did not modifythe association between diet quality and survival. CONCLUSION: Our results suggest that overall higher prediagnosis diet quality may protect against mortality after ovarian cancer.
    Source
    J Natl Cancer Inst. 2014 Oct 21;106(11). pii: dju314. doi: 10.1093/jnci/dju314. Print 2014 Nov . Link to article on publisher's site
    DOI
    10.1093/jnci/dju314
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44609
    PubMed ID
    25335480
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/jnci/dju314
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