Elevated Depressive Symptoms, Antidepressant Use, and Diabetes in a Large Multiethnic National Sample of Postmenopausal Women
Authors
Ma, YunshengBalasubramanian, Raji
Pagoto, Sherry L.
Schneider, Kristin L.
Culver, Annie L.
Olendzki, Barbara C.
Tinker, Lesley
Liu, Simin
Safford, Monika M.
Sepavich, Deidre M.
Rosal, Milagros C.
Ockene, Judith K.
Carnethon, Mercedes
Zorn, Martha
Hebert, James R.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2011-11-01Keywords
PostmenopauseDepression
Antidepressive Agents
Diabetes Mellitus
Women's Health
Behavioral Disciplines and Activities
Behavior and Behavior Mechanisms
Community Health and Preventive Medicine
Mental Disorders
Preventive Medicine
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE To examine elevated depressive symptoms and antidepressant use in relation to diabetes incidence in the Women’s Health Initiative. RESEARCH DESIGN AND METHODS A total of 161,808 postmenopausal women were followed for over an average of 7.6 years. Hazard ratios (HRs) estimating the effects of elevated depressive symptoms and antidepressant use on newly diagnosed incident diabetes were obtained using Cox proportional hazards models adjusted for known diabetes risk factors. RESULTS Multivariable-adjusted HRs indicated an increased risk of incident diabetes with elevated baseline depressive symptoms (HR 1.14 [95% CI 1.08–1.21]) and antidepressant use (1.20 [1.09–1.32]). These associations persisted in year 3 data, in which respective adjusted HRs were 1.23 (1.09–1.39) and 1.31 (1.14–1.50). CONCLUSIONS Postmenopausal women with elevated depressive symptoms and who use antidepressants have a greater risk of developing incident diabetes. In addition, longstanding elevated depressive symptoms and recent antidepressant medication use increase the risk of incident diabetes.Source
Diabetes Care. 2011 Nov;34(11):2390-2. Epub 2011 Sep 12. DOI: 10.2337/dc11-1223. Link to article on publisher's websiteDOI
10.2337/dc11-1223Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44733PubMed ID
21911776Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.2337/dc11-1223