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    Androstenediol complements estrogenic bioactivity during the menopausal transition

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    Authors
    Lasley, William L.
    Chen, Jiangang
    Stanczyk, Frank Z.
    El Khoudary, Samar R.
    Gee, Nancy A.
    Crawford, Sybil L.
    McConnell, Daniel S.
    UMass Chan Affiliations
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Document Type
    Journal Article
    Publication Date
    2012-06-01
    Keywords
    Adult
    Androstenediol
    Androstenedione
    Dehydroepiandrosterone
    Dehydroepiandrosterone Sulfate
    Estradiol
    Female
    Humans
    Middle Aged
    Perimenopause
    Testosterone
    Endocrinology
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    Link to Full Text
    http://dx.doi.org/10.1097/gme.0b013e31823df577
    Abstract
    OBJECTIVE: The perimenopausal increase in circulating dehydroepiandrosterone sulfate (DHEAS) levels during the menopausal transition (MT) is accompanied by other adrenal steroids that have the potential to alter estrogen/androgen balance and explain the wide interwoman range of estrogen-related symptoms experienced during the MT. METHODS: Annual serum samples from the Study of Women's Health Across the Nation, which had previously been analyzed for immunoreactive estradiol (E2), testosterone, DHEAS, and sex hormone-binding globulin, were selected based on DHEAS concentration and analyzed for immunoreactive and bioactive estrogens and androgens, including immunoreactive androstenedione, dehydroepiandrosterone, and 5-androstene-3beta,17beta-diol (androstenediol [Adiol]). RESULTS: A two-fold increase in circulating androstenedione and testosterone was found to rise in parallel with the rise in circulating DHEAS, whereas dehydroepiandrosterone and Adiol concentrations rose seven- to eight-fold. Circulating Adiol, which has both androgenic and estrogenic biological activity, was significantly associated (P < 0.02) with circulating estrogen bioactivity only when E2 concentrations were low and Adiol levels were high. CONCLUSIONS: The wide range of circulating levels of Adiol and its contribution to total circulating estrogenicity during the MT is consistent with the observed interwoman difference in symptoms at this time. Therefore, we conclude that Adiol contributes to circulating estrogenicity when E2 production falls at menopause and may contribute significantly to the endocrine changes experienced by midlife women.
    Source
    Menopause. 2012 Jun;19(6):650-7. Link to article on publisher's site
    DOI
    10.1097/gme.0b013e31823df577
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44814
    PubMed ID
    22415563
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1097/gme.0b013e31823df577
    Scopus Count
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    Population and Quantitative Health Sciences Publications

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