Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging
Authors
Harlow, Sioban D.Gass, Margery
Hall, Janet E.
Lobo, Roger
Maki, Pauline M.
Rebar, Robert W.
Sherman, Sherry S.
Sluss, Patrick M.
de Villiers, Tobie J.
Crawford, Sybil L.
UMass Chan Affiliations
Department of Preventative and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2012-04-01Keywords
AgingAnti-Mullerian Hormone
Biological Markers
Biomedical Research
Cohort Studies
Congresses as Topic
Endocrine System Diseases
Female
Humans
Hypothalamo-Hypophyseal System
Menopause
Ovary
Reproduction
*Women's Health
Physiology
Metadata
Show full item recordAbstract
OBJECTIVE: The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. METHODS: Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimullerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. RESULTS: STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. CONCLUSIONS: STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.Source
Menopause. 2012 Apr;19(4):387-95. Link to article on publisher's siteDOI
10.1097/gme.0b013e31824d8f40Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44816PubMed ID
22343510Notes
Sybil L. Crawford is a collaborator in the STRAW+10 Collaborative Group.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/gme.0b013e31824d8f40