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    A pilot study of nadolol for overt aggression in developmentally delayed individuals

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    Authors
    Connor, Daniel F.
    Ozbayrak, Kaan R.
    Benjamin, Sheldon
    Ma, Yunsheng
    Fletcher, Kenneth E.
    UMass Chan Affiliations
    Department of Psychiatry
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Document Type
    Journal Article
    Publication Date
    1997-06-01
    Keywords
    Adolescent
    Adrenergic beta-Antagonists
    Adult
    Aggression
    Child
    Developmental Disabilities
    Humans
    Male
    Nadolol
    Pilot Projects
    Prospective Studies
    Treatment Outcome
    Behavioral Disciplines and Activities
    Behavior and Behavior Mechanisms
    Community Health and Preventive Medicine
    Preventive Medicine
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    Link to Full Text
    http://dx.doi.org/10.1097/00004583-199706000-00021
    Abstract
    OBJECTIVE: The aim of this preliminary pilot study was to investigate the safety and efficacy of open-label nadolol as an adjunctive pharmacological treatment for aggression and/or inattention/overactivity in a developmentally delayed child, adolescent, and young adult population. METHOD: Twelve subjects enrolled and completed (mean age 13.8 years, range 9 through 24) a 5-month, open, prospective protocol of nadolol (mean dose 109 mg, range 30 through 220 mg) with systematic baseline and outcome evaluations and weekly clinical assessment. RESULTS: All subjects were developmentally delayed and most were cognitively delayed. Ten subjects (83%) showed clinical improvement while receiving nadolol. Significant improvements were noted on observer-rated overt categorical aggression, severity of illness, and global impressions of improvement. No significant effects were found for inattention/overactivity. Nadolol was well tolerated, with few side effects. CONCLUSIONS: Overt categorical aggression presenting in developmentally delayed children, adolescents, and young adults may respond to nadolol treatment.
    Source
    J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):826-34.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44817
    PubMed ID
    9183139
    Related Resources
    Link to article in PubMed
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    Population and Quantitative Health Sciences Publications

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