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dc.contributor.authorChan, Kei Hang K.
dc.contributor.authorNiu, Tianhua
dc.contributor.authorMa, Yunsheng
dc.contributor.authorYou, Nai-chieh Y
dc.contributor.authorSong, Yiqing
dc.contributor.authorSobel, Eric M.
dc.contributor.authorHsu, Yi-Hsiang
dc.contributor.authorBalasubramanian, Raji
dc.contributor.authorQiao, Yongxia
dc.contributor.authorTinker, Lesley F.
dc.contributor.authorLiu, Simin
dc.date2022-08-11T08:10:21.000
dc.date.accessioned2022-08-23T17:05:23Z
dc.date.available2022-08-23T17:05:23Z
dc.date.issued2013-03-01
dc.date.submitted2013-06-21
dc.identifier.citationJ Clin Endocrinol Metab. 2013 Mar;98(3):E600-4. doi: 10.1210/jc.2012-3644. <a href="http://dx.doi.org/10.1210/jc.2012-3644" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn0021-972X (Linking)
dc.identifier.doi10.1210/jc.2012-3644
dc.identifier.pmid23386649
dc.identifier.urihttp://hdl.handle.net/20.500.14038/44846
dc.description.abstractCONTEXT: Peroxisome proliferator-activated receptor-gamma (PPARG) plays a pivotal role in adipogenesis and glucose homeostasis. OBJECTIVE: We investigated whether PPARG gene variants were associated with type 2 diabetes (T2D) risk in the multiethnic Women's Health Initiative (WHI). RESEARCH DESIGN AND METHODS: We assessed PPARG single-nucleotide polymorphisms (SNPs) in a case-control study nested in the prospective WHI observational study (WHI-OS) (1543 T2D cases and 2170 matched controls). After identifying 24 tagSNPs, we used multivariable logistic regression models and haplotype-based analyses to estimate these tagSNP-T2D associations. Single-SNP analyses were also conducted in another study of 5642 African American and Hispanic American women in the WHI SNP Health Association Resource (WHI-SHARe). RESULTS: We found a borderline significant association between the Pro12Ala (rs1801282) variant and T2D risk in WHI-OS [odds ratio (OR) 0.51, 95% confidence interval (CI) 0.31-0.83, P = .01, combined group, additive model; P = .04, Hispanic American] and WHI-SHARe (OR 0.25, 95% CI 0.08-0.77, P = .02, Hispanic American) participants. In promoter region, rs6809631, rs9817428, rs10510411, rs12629293, and rs12636454 were also associated with T2D risk (range ORs 0.68-0.78, 95% CIs 0.52-0.91 to 0.60-1.00, P CONCLUSIONS: The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. Additional significant loci included 5 PPARG promoter variants.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23386649&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1210/jc.2012-3644
dc.subjectAdipogenesis
dc.subjectAfrican Americans
dc.subjectAged
dc.subjectAsian Americans
dc.subjectBlood Glucose
dc.subjectCase-Control Studies
dc.subjectDiabetes Mellitus, Type 2
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectHaplotypes
dc.subjectHispanic Americans
dc.subjectHumans
dc.subjectLogistic Models
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectPPAR gamma
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPostmenopause
dc.subjectRisk Factors
dc.subjectUnited States
dc.subjectCellular and Molecular Physiology
dc.subjectEndocrinology
dc.subjectNutritional and Metabolic Diseases
dc.subjectWomen's Health
dc.titleCommon genetic variants in peroxisome proliferator-activated receptor-gamma (PPARG) and type 2 diabetes risk among Women's Health Initiative postmenopausal women
dc.typeJournal Article
dc.source.journaltitleThe Journal of clinical endocrinology and metabolism
dc.source.volume98
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/prevbeh_pp/268
dc.identifier.contextkey4250970
html.description.abstract<p>CONTEXT: Peroxisome proliferator-activated receptor-gamma (PPARG) plays a pivotal role in adipogenesis and glucose homeostasis.</p> <p>OBJECTIVE: We investigated whether PPARG gene variants were associated with type 2 diabetes (T2D) risk in the multiethnic Women's Health Initiative (WHI).</p> <p>RESEARCH DESIGN AND METHODS: We assessed PPARG single-nucleotide polymorphisms (SNPs) in a case-control study nested in the prospective WHI observational study (WHI-OS) (1543 T2D cases and 2170 matched controls). After identifying 24 tagSNPs, we used multivariable logistic regression models and haplotype-based analyses to estimate these tagSNP-T2D associations. Single-SNP analyses were also conducted in another study of 5642 African American and Hispanic American women in the WHI SNP Health Association Resource (WHI-SHARe).</p> <p>RESULTS: We found a borderline significant association between the Pro12Ala (rs1801282) variant and T2D risk in WHI-OS [odds ratio (OR) 0.51, 95% confidence interval (CI) 0.31-0.83, P = .01, combined group, additive model; P = .04, Hispanic American] and WHI-SHARe (OR 0.25, 95% CI 0.08-0.77, P = .02, Hispanic American) participants. In promoter region, rs6809631, rs9817428, rs10510411, rs12629293, and rs12636454 were also associated with T2D risk (range ORs 0.68-0.78, 95% CIs 0.52-0.91 to 0.60-1.00, P</p> <p>CONCLUSIONS: The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. Additional significant loci included 5 PPARG promoter variants.</p>
dc.identifier.submissionpathprevbeh_pp/268
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pagesE600-4


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