Multivitamin and mineral use and breast cancer mortality in older women with invasive breast cancer in the women's health initiative
Authors
Wassertheil-Smoller, SylviaMcGinn, A P.
Budrys, N.
Chlebowski, Rowan T.
Ho, G. Y.
Johnson, K. C.
Lane, D. S.
Li, Wenjun
Neuhouser, Marian L.
Saquib, J.
Shikany, James M.
Song, Y.
Thomson, Cynthia A.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2013-10-10Keywords
AgedBreast Neoplasms
Carcinoma, Ductal, Breast
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Minerals
Postmenopause
Proportional Hazards Models
Prospective Studies
Vitamins
Behavioral Disciplines and Activities
Behavior and Behavior Mechanisms
Clinical Epidemiology
Community Health and Preventive Medicine
Epidemiology
Neoplasms
Preventive Medicine
Women's Health
Metadata
Show full item recordAbstract
Multivitamin use is common in the United States. It is not known whether multivitamins with minerals supplements (MVM) used by women already diagnosed with invasive breast cancer would affect their breast cancer mortality risk. To determine prospectively the effects of MVM use on breast cancer mortality in postmenopausal women diagnosed with invasive breast cancer, a prospective cohort study was conducted of 7,728 women aged 50-79 at enrollment in the women's health initiative (WHI) in 40 clinical sites across the United States diagnosed with incident invasive breast cancer during WHI and followed for a mean of 7.1 years after breast cancer diagnosis. Use of MVM supplements was assessed at WHI baseline visit and at visit closest to breast cancer diagnosis, obtained from vitamin pill bottles brought to clinic visit. Outcome was breast cancer mortality. Hazard ratios and 95 % confidence intervals (CIs) for breast cancer mortality comparing MVM users to non-users were estimated using Cox proportional hazard regression models. Analyses using propensity to take MVM were done to adjust for potential differences in characteristics of MVM users versus non-users. At baseline, 37.8 % of women reported MVM use. After mean post-diagnosis follow-up of 7.1 +/- 4.1 (SD) years, there were 518 (6.7 %) deaths from breast cancer. In adjusted analyses, breast cancer mortality was 30 % lower in MVM users as compared to non-users (HR = 0.70; 95 % CI 0.55, 0.91). This association was highly robust and persisted after multiple adjustments for potential confounding variables and in propensity score matched analysis (HR = 0.76; 95 % CI 0.60-0.96). Postmenopausal women with invasive breast cancer using MVM had lower breast cancer mortality than non-users. The results suggest a possible role for daily MVM use in attenuating breast cancer mortality in women with invasive breast cancer but the findings require confirmation.Source
Wassertheil-Smoller S, McGinn AP, Budrys N, Chlebowski R, Ho GY, Johnson KC, Lane DS, Li W, Neuhouser ML, Saquib J, Shikany JM, Song Y, Thomson C. Multivitamin and mineral use and breast cancer mortality in older women with invasive breast cancer in the women's health initiative. Breast Cancer Res Treat. 2013 Oct;141(3):495-505. doi: 10.1007/s10549-013-2712-x.DOI
10.1007/s10549-013-2712-xPermanent Link to this Item
http://hdl.handle.net/20.500.14038/44853PubMed ID
24104882Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s10549-013-2712-x