Factors contributing to spontaneous Enterocytozoon bieneusi infection in simian immunodeficiency virus-infected macaques
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2006-12-12Keywords
AnimalsBody Composition
CD4 Lymphocyte Count
Dietary Supplements
Disease Progression
Enterocytozoon
Macaca mulatta
Microsporidiosis
Risk Factors
Simian Acquired Immunodeficiency Syndrome
Viral Load
Immunology and Infectious Disease
Infectious Disease
Veterinary Medicine
Metadata
Show full item recordAbstract
BACKGROUND: A cohort of SIV-infected macaques had been used to investigate the effect of dietary supplement, immune status, SIV/AIDS disease progression and serum micronutrients levels on spontaneous acquisition of Enterocytozoon bieneusi infection in SIV-infected macaques. METHODS: Twenty-four SIV-infected macaques were randomized into 2 groups. One group received a vitamin/mineral supplementation and a second group received a placebo. Both groups were examined for E. bieneusi infection. RESULTS: SIV-infected macaques were more prone to acquire E. bieneusi with the progression of SIV/AIDS, and the increased shedding of infectious spores was directly associated with decreased CD4 lymphocyte and increased circulating SIV, in both supplemented and unsupplemented groups of animals. Dietary supplementation, body composition factors and serum micronutrients levels however had no association with the acquisition of E. bieneusi infection in these animals. CONCLUSIONS: Acquisition of E. bieneusi infection is related to SIV disease progression, CD4 counts and viral load but independent of changes in body composition and serum micronutrient levels.Source
J Med Primatol. 2006 Dec;35(6):352-60. Link to article on publisher's siteDOI
10.1111/j.1600-0684.2006.00181.xPermanent Link to this Item
http://hdl.handle.net/20.500.14038/44875PubMed ID
17214663Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1111/j.1600-0684.2006.00181.x