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dc.contributor.authorGerace, Terence A.
dc.contributor.authorHollis, Jack F.
dc.contributor.authorOckene, Judith K.
dc.contributor.authorSvendsen, Kenneth H.
dc.date2022-08-11T08:10:22.000
dc.date.accessioned2022-08-23T17:05:47Z
dc.date.available2022-08-23T17:05:47Z
dc.date.issued1991-09-01
dc.date.submitted2008-01-25
dc.identifier.citationPrev Med. 1991 Sep;20(5):602-20.
dc.identifier.issn0091-7435 (Print)
dc.identifier.pmid1758841
dc.identifier.urihttp://hdl.handle.net/20.500.14038/44935
dc.description.abstractCigarette smoking cessation was examined for its impact on diastolic blood pressure, weight, and plasma lipids in 3,470 special intervention males in the Multiple Risk Factor Intervention Trial. Change in smoking status (quitters vs nonquitters) was not independently associated with change in diastolic blood pressure or the subsequent use of antihypertensive medication for smokers who were normotensive at entry. More quitters (35%) became hypertensive than nonquitters (27%, P less than 0.01), although the groups had similar baseline diastolic blood pressure levels. Weight gain subsequent to cessation probably contributed to this excess incidence of hypertension in quitters. Stepped-care antihypertensive therapy lowered diastolic blood pressure similarly for hypertensive quitters and nonquitters. Weight increases of 6 lb or more by the 72-month visit occurred in 47% of quitters vs 25% of nonquitters (P less than 0.01); quitters did not differ from nonquitters in their change in total kilocalories from baseline to the 72-month visit. Quitters who gained 6 lb or more tended to be less obese at baseline, be less physically active, and smoke more cigarettes per day than those who did not gain this amount. Finally, quitters relative to nonquitters experienced an adjusted increase of 2.4 mg/dl high-density lipoprotein cholesterol, but no difference in total or low-density lipoprotein cholesterol. The implications for intervention are discussed as they relate to the common, but not inevitable, increase in weight subsequent to cessation.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1758841&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/0091-7435(91)90058-C
dc.subjectAntihypertensive Agents
dc.subjectBlood Pressure
dc.subjectExertion
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectHypertension
dc.subjectIncidence
dc.subjectIntervention Studies
dc.subjectLipoproteins
dc.subjectMale
dc.subjectRisk Factors
dc.subjectSmoking
dc.subjectWeight Gain
dc.subjectBehavioral Disciplines and Activities
dc.subjectCommunity Health and Preventive Medicine
dc.subjectPreventive Medicine
dc.titleSmoking cessation and change in diastolic blood pressure, body weight, and plasma lipids. MRFIT Research Group
dc.typeJournal Article
dc.source.journaltitlePreventive medicine
dc.source.volume20
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/prevbeh_pp/49
dc.identifier.contextkey418534
html.description.abstract<p>Cigarette smoking cessation was examined for its impact on diastolic blood pressure, weight, and plasma lipids in 3,470 special intervention males in the Multiple Risk Factor Intervention Trial. Change in smoking status (quitters vs nonquitters) was not independently associated with change in diastolic blood pressure or the subsequent use of antihypertensive medication for smokers who were normotensive at entry. More quitters (35%) became hypertensive than nonquitters (27%, P less than 0.01), although the groups had similar baseline diastolic blood pressure levels. Weight gain subsequent to cessation probably contributed to this excess incidence of hypertension in quitters. Stepped-care antihypertensive therapy lowered diastolic blood pressure similarly for hypertensive quitters and nonquitters. Weight increases of 6 lb or more by the 72-month visit occurred in 47% of quitters vs 25% of nonquitters (P less than 0.01); quitters did not differ from nonquitters in their change in total kilocalories from baseline to the 72-month visit. Quitters who gained 6 lb or more tended to be less obese at baseline, be less physically active, and smoke more cigarettes per day than those who did not gain this amount. Finally, quitters relative to nonquitters experienced an adjusted increase of 2.4 mg/dl high-density lipoprotein cholesterol, but no difference in total or low-density lipoprotein cholesterol. The implications for intervention are discussed as they relate to the common, but not inevitable, increase in weight subsequent to cessation.</p>
dc.identifier.submissionpathprevbeh_pp/49
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages602-20


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