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dc.contributor.authorLuo, Yingyi
dc.contributor.authorLi, Xiankai
dc.contributor.authorLi, Jue
dc.contributor.authorWang, Xiaoming
dc.contributor.authorQiao, Yongxia
dc.contributor.authorHu, Dayi
dc.contributor.authorMerriam, Philip A.
dc.contributor.authorMa, Yunsheng
dc.date2022-08-11T08:10:22.000
dc.date.accessioned2022-08-23T17:05:48Z
dc.date.available2022-08-23T17:05:48Z
dc.date.issued2010-03-09
dc.date.submitted2010-03-12
dc.identifier.citationJ Vasc Surg. 2010 Mar;51(3):673-678. <a href="http://dx.doi.org/10.1016/j.jvs.2009.09.024">Link to article on publisher's site</a>
dc.identifier.issn0741-5214 (Linking)
dc.identifier.doi10.1016/j.jvs.2009.09.024
dc.identifier.pmid20206811
dc.identifier.urihttp://hdl.handle.net/20.500.14038/44940
dc.description.abstractOBJECTIVE: Smoking is a major risk factor for peripheral arterial disease (PAD), and PAD is associated with all-cause and cardiovascular disease (CVD) mortality. The objective of this study was to determine the combined effects of smoking and PAD on all-cause and CVD mortality. METHODS: A total of 1979 males 35 years of age or older were enrolled from eight university-affiliated hospitals in Beijing and Shanghai in 2004, with both smoking status and PAD diagnosis obtained, 1712 of them had complete follow-up data. Mortality data were obtained from all participants between December 2007 and February 2008. Cox proportional hazards models were used to evaluate relative risks (RRs) of all-cause mortality and CVD mortality among different groups. RESULTS: At baseline, the average age of participants was 66.98-years-old (SD = 11.57), prevalence of PAD was 24.0% and 65.4% smoked cigarettes. During the 3-year follow-up, all-cause cumulative mortality rates were 27.9% (PAD/smoker), 26.3% (PAD/nonsmoker), 14.1% (no PAD/smoker), and 14.4% (no PAD/nonsmoker) (P < .001), and CVD cumulative mortality rates were 17.8%, 14.9%, 8.1%, and 7.3%, respectively (P < .001). Compared with the no PAD/nonsmoker subjects, adjusted RR from all-cause mortality in the groups of both PAD/smoker, PAD/nonsmoker, and no PAD/smoker were 1.88 (95% confidence interval [CI], 1.34-2.64), 1.37 (95% CI, 0.85-2.23), and 1.08 (95% CI, 0.79-1.49), respectively. The adjusted RR from CVD mortality was 2.12 (95% CI, 1.37-3.28), 1.55 (95% CI, 0.84-2.86), and 1.13 (95% CI, 0.74-1.71), respectively. CONCLUSION: PAD is a major determinant of mortality. Smoking did not contribute to mortality in this study. Further research is needed.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20206811&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.jvs.2009.09.024
dc.subjectBehavioral Disciplines and Activities
dc.subjectBehavior and Behavior Mechanisms
dc.subjectCommunity Health and Preventive Medicine
dc.subjectPreventive Medicine
dc.titleCombined effects of smoking and peripheral arterial disease on all-cause and cardiovascular disease mortality in a Chinese male cohort
dc.typeArticle
dc.source.journaltitleJournal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter
dc.source.volume51
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/prevbeh_pp/54
dc.identifier.contextkey1219020
html.description.abstract<p>OBJECTIVE: Smoking is a major risk factor for peripheral arterial disease (PAD), and PAD is associated with all-cause and cardiovascular disease (CVD) mortality. The objective of this study was to determine the combined effects of smoking and PAD on all-cause and CVD mortality.</p> <p>METHODS: A total of 1979 males 35 years of age or older were enrolled from eight university-affiliated hospitals in Beijing and Shanghai in 2004, with both smoking status and PAD diagnosis obtained, 1712 of them had complete follow-up data. Mortality data were obtained from all participants between December 2007 and February 2008. Cox proportional hazards models were used to evaluate relative risks (RRs) of all-cause mortality and CVD mortality among different groups.</p> <p>RESULTS: At baseline, the average age of participants was 66.98-years-old (SD = 11.57), prevalence of PAD was 24.0% and 65.4% smoked cigarettes. During the 3-year follow-up, all-cause cumulative mortality rates were 27.9% (PAD/smoker), 26.3% (PAD/nonsmoker), 14.1% (no PAD/smoker), and 14.4% (no PAD/nonsmoker) (P < .001), and CVD cumulative mortality rates were 17.8%, 14.9%, 8.1%, and 7.3%, respectively (P < .001). Compared with the no PAD/nonsmoker subjects, adjusted RR from all-cause mortality in the groups of both PAD/smoker, PAD/nonsmoker, and no PAD/smoker were 1.88 (95% confidence interval [CI], 1.34-2.64), 1.37 (95% CI, 0.85-2.23), and 1.08 (95% CI, 0.79-1.49), respectively. The adjusted RR from CVD mortality was 2.12 (95% CI, 1.37-3.28), 1.55 (95% CI, 0.84-2.86), and 1.13 (95% CI, 0.74-1.71), respectively.</p> <p>CONCLUSION: PAD is a major determinant of mortality. Smoking did not contribute to mortality in this study. Further research is needed.</p>
dc.identifier.submissionpathprevbeh_pp/54
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages673-678


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