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    Association of glycemic load with cardiovascular disease risk factors: The Women's Health Initiative Observational Study

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    Authors
    Shikany, James M.
    Tinker, Lesley F.
    Neuhouser, Marian L.
    Ma, Yunsheng
    Patterson, Ruth E.
    Phillips, Lawrence S.
    Liu, Simin
    Redden, David T.
    UMass Chan Affiliations
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Document Type
    Journal Article
    Publication Date
    2010-06-01
    Keywords
    Behavioral Disciplines and Activities
    Behavior and Behavior Mechanisms
    Cardiovascular Diseases
    Community Health and Preventive Medicine
    Preventive Medicine
    Women's Health
    
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    http://dx.doi.org/10.1016/j.nut.2009.08.014
    Abstract
    OBJECTIVE: Associations between dietary glycemic load (GL) and cardiovascular disease risk factors, including plasma lipoprotein/lipid levels, blood pressure, and glucose metabolism factors, in the Women's Health Initiative Observational Study were examined. METHODS: A random sample of 878 Observational Study participants (postmenopausal women 50-79 y of age) with baseline blood measurements (647 white, 104 black, 127 Hispanic) was included. Dietary GL was estimated from baseline food-frequency questionnaires, which assessed dietary intake over the previous 3 mo. At the baseline visit, participants completed demographic and health habit questionnaires, fasting blood samples were collected, anthropometric measurements were completed, and blood pressure was assessed. RESULTS: In all participants combined, GL was inversely associated with high-density lipoprotein cholesterol (P for trend = 0.004) and positively associated with log(10)-transformed triacylglycerols (P = 0.008). Although there were no statistically significant interactions of race/ethnicity with associations between GL and cardiovascular disease risk factors, stratified results were suggestive, showing that GL was positively associated with total cholesterol (P = 0.018) and low-density lipoprotein cholesterol (P = 0.038) in Hispanics. In white subjects, there was a trend of reduced high-density lipoprotein cholesterol with higher GL (P = 0.003), whereas GL was positively associated with log(10)-transformed triacylglycerols (P = 0.015). Associations between GL and high-density lipoprotein cholesterol and between GL and triacylglycerols also differed by body mass index, although the interactions were not statistically significant. CONCLUSION: Among these generally healthy postmenopausal women, GL was associated with high-density lipoprotein cholesterol and triacylglycerols. Suggestive effects of race/ethnicity and body mass index on these associations need to be confirmed in larger studies.
    Source
    Nutrition. 2010 Jun;26(6):641-7. doi: 10.1016/j.nut.2009.08.014. Link to article on publisher's site
    DOI
    10.1016/j.nut.2009.08.014
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/44955
    PubMed ID
    20053533
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.nut.2009.08.014
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    Population and Quantitative Health Sciences Publications

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