Fluoxetine, smoking, and history of major depression: A randomized controlled trial
Authors
Spring, Bonnie J.Doran, Neal
Pagoto, Sherry L.
McChargue, Dennis
Werth Cook, Jessica
Bailey, Katherine
Crayton, John
Hedeker, Donald
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2007-02-14Keywords
AdolescentAdult
*Depressive Disorder, Major
Fluoxetine
Follow-Up Studies
Humans
Middle Aged
Questionnaires
Serotonin Uptake Inhibitors
Smoking
Behavioral Disciplines and Activities
Behavior and Behavior Mechanisms
Community Health and Preventive Medicine
Preventive Medicine
Metadata
Show full item recordAbstract
The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.Source
J Consult Clin Psychol. 2007 Feb;75(1):85-94. Link to article on publisher's siteDOI
10.1037/0022-006X.75.1.85Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44988PubMed ID
17295567Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1037/0022-006X.75.1.85