Fluoxetine, smoking, and history of major depression: A randomized controlled trial
AuthorsSpring, Bonnie J.
Pagoto, Sherry L.
Werth Cook, Jessica
UMass Chan AffiliationsDepartment of Medicine, Division of Preventive and Behavioral Medicine
*Depressive Disorder, Major
Serotonin Uptake Inhibitors
Behavioral Disciplines and Activities
Behavior and Behavior Mechanisms
Community Health and Preventive Medicine
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AbstractThe study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
SourceJ Consult Clin Psychol. 2007 Feb;75(1):85-94. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/44988
Related ResourcesLink to Article in PubMed