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Apparent neuroleptic malignant syndrome with clozapine and lithium

dc.contributor.authorPope, Harrison G.
dc.contributor.authorCole, J. O.
dc.contributor.authorChoras, P. T.
dc.contributor.authorFulwiler, Carl E.
dc.date2022-08-11T08:10:22.000
dc.date.accessioned2022-08-23T17:06:03Z
dc.date.available2022-08-23T17:06:03Z
dc.date.issued1986-08-01
dc.date.submitted2010-02-10
dc.identifier.citationJ Nerv Ment Dis. 1986 Aug;174(8):493-5.
dc.identifier.issn0022-3018 (Linking)
dc.identifier.pmid3090198
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45001
dc.description.abstractClozapine is an antipsychotic drug reported to be virtually free of extrapyramidal effects. On the basis of this, we hypothesized that it would be unlikely to cause the neuroleptic malignant syndrome (NMS), a rare but severe reaction observed with other antipsychotic drugs. However, when we administered clozapine (in conjunction with lithium) to a patient with a past history of NMS with fluphenazine, the syndrome reappeared after about 3 weeks of treatment. This represents, to our knowledge, the first report of apparent NMS with clozapine.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=3090198&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://journals.lww.com/jonmd/Abstract/1986/08000/Apparent_Neuroleptic_Malignant_Syndrome_with.10.aspx
dc.subjectAdult
dc.subjectBipolar Disorder
dc.subjectClozapine
dc.subjectDibenzazepines
dc.subjectDrug Therapy, Combination
dc.subjectFluphenazine
dc.subjectHumans
dc.subjectLithium
dc.subjectLithium Carbonate
dc.subjectMale
dc.subjectNeuroleptic Malignant Syndrome
dc.subjectHealth Services Research
dc.subjectMental and Social Health
dc.subjectPsychiatric and Mental Health
dc.subjectPsychiatry
dc.subjectPsychiatry and Psychology
dc.titleApparent neuroleptic malignant syndrome with clozapine and lithium
dc.typeJournal Article
dc.source.journaltitleThe Journal of nervous and mental disease
dc.source.volume174
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_cmhsr/11
dc.identifier.contextkey1139411
html.description.abstract<p>Clozapine is an antipsychotic drug reported to be virtually free of extrapyramidal effects. On the basis of this, we hypothesized that it would be unlikely to cause the neuroleptic malignant syndrome (NMS), a rare but severe reaction observed with other antipsychotic drugs. However, when we administered clozapine (in conjunction with lithium) to a patient with a past history of NMS with fluphenazine, the syndrome reappeared after about 3 weeks of treatment. This represents, to our knowledge, the first report of apparent NMS with clozapine.</p>
dc.identifier.submissionpathpsych_cmhsr/11
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages493-5


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