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    Hydrogen and potassium regulation of (pro)renin processing and secretion

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    Authors
    King, Jean A.
    Fray, John
    UMass Chan Affiliations
    Department of Physiology
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    1994-07-01
    Keywords
    Animals
    Endocrine System Diseases
    Enzyme Precursors
    Humans
    Hydrogen
    Potassium
    *Protein Processing, Post-Translational
    Renin
    Health Services Research
    Mental and Social Health
    Psychiatric and Mental Health
    Psychiatry
    Psychiatry and Psychology
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    Link to Full Text
    http://ajprenal.physiology.org/cgi/reprint/267/1/F1
    Abstract
    H and K ions play central roles in prorenin processing and secretion, and prorenin is abnormally expressed in H and K disorders. At the surface membrane of juxtaglomerular (JG) cells, K is sensed and regulated by K channels (coupled to Cl channels and activated by excess Ca), Na-K-adenosinetriphosphatase, and a KCl/H exchange transporter (regulated by Ca). In JG cell granular membrane, K flux is regulated by K channels and a KCl/H exchange transporter (activated by Ca). H channels and a H pump reside in the granular membrane, which maintain H concentration in the granular matrix at least two orders of magnitude greater than in cytosol. The H pump may also be responsible for maintaining the acidic matrix required for maximal prorenin processing to renin by prohormone convertase for human renin (PCren), the prorenin convertase. These molecules form the core of a chemiosmotic system, which appears to regulate both prorenin processing and renin secretion. Renin secretion and prorenin processing appear to be of more than causal significance in clinical disorders characterized by chemiosmotic imbalance. A critical review of the literature supports the following general conclusions. First, hyperrenin state defines the initial phase in the pathogenesis of heart disease, diabetes mellitus, and hypertension. Second, low-renin syndrome defines the transition-to-establish phase in the pathogenesis of heart disease, diabetes mellitus, and hypertension in which the key feature is renin secretory hyporesponsivity. Third, renin disorders are usually associated with other endocrine disorders (polyendocrinopathies types I, II, and III), suggesting that renin may be an important molecule in the processing of chemiosmotic forces. The key chemiosmotic molecules (K and H) are also important in the processing and export of most (if not all) hormones. Thus, by regulating K and H homeostasis, renin may regulate the endocrine system.
    Source
    Am J Physiol. 1994 Jul;267(1 Pt 2):F1-12.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45022
    PubMed ID
    8048549
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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