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dc.contributor.authorKing, Jean A.
dc.contributor.authorFray, John
dc.date2022-08-11T08:10:22.000
dc.date.accessioned2022-08-23T17:06:09Z
dc.date.available2022-08-23T17:06:09Z
dc.date.issued1994-07-01
dc.date.submitted2010-11-03
dc.identifier.citationAm J Physiol. 1994 Jul;267(1 Pt 2):F1-12.
dc.identifier.issn0002-9513 (Linking)
dc.identifier.pmid8048549
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45022
dc.description.abstractH and K ions play central roles in prorenin processing and secretion, and prorenin is abnormally expressed in H and K disorders. At the surface membrane of juxtaglomerular (JG) cells, K is sensed and regulated by K channels (coupled to Cl channels and activated by excess Ca), Na-K-adenosinetriphosphatase, and a KCl/H exchange transporter (regulated by Ca). In JG cell granular membrane, K flux is regulated by K channels and a KCl/H exchange transporter (activated by Ca). H channels and a H pump reside in the granular membrane, which maintain H concentration in the granular matrix at least two orders of magnitude greater than in cytosol. The H pump may also be responsible for maintaining the acidic matrix required for maximal prorenin processing to renin by prohormone convertase for human renin (PCren), the prorenin convertase. These molecules form the core of a chemiosmotic system, which appears to regulate both prorenin processing and renin secretion. Renin secretion and prorenin processing appear to be of more than causal significance in clinical disorders characterized by chemiosmotic imbalance. A critical review of the literature supports the following general conclusions. First, hyperrenin state defines the initial phase in the pathogenesis of heart disease, diabetes mellitus, and hypertension. Second, low-renin syndrome defines the transition-to-establish phase in the pathogenesis of heart disease, diabetes mellitus, and hypertension in which the key feature is renin secretory hyporesponsivity. Third, renin disorders are usually associated with other endocrine disorders (polyendocrinopathies types I, II, and III), suggesting that renin may be an important molecule in the processing of chemiosmotic forces. The key chemiosmotic molecules (K and H) are also important in the processing and export of most (if not all) hormones. Thus, by regulating K and H homeostasis, renin may regulate the endocrine system.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8048549&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://ajprenal.physiology.org/cgi/reprint/267/1/F1
dc.subjectAnimals
dc.subjectEndocrine System Diseases
dc.subjectEnzyme Precursors
dc.subjectHumans
dc.subjectHydrogen
dc.subjectPotassium
dc.subject*Protein Processing, Post-Translational
dc.subjectRenin
dc.subjectHealth Services Research
dc.subjectMental and Social Health
dc.subjectPsychiatric and Mental Health
dc.subjectPsychiatry
dc.subjectPsychiatry and Psychology
dc.titleHydrogen and potassium regulation of (pro)renin processing and secretion
dc.typeJournal Article
dc.source.journaltitleThe American journal of physiology
dc.source.volume267
dc.source.issue1 Pt 2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_cmhsr/131
dc.identifier.contextkey1628898
html.description.abstract<p>H and K ions play central roles in prorenin processing and secretion, and prorenin is abnormally expressed in H and K disorders. At the surface membrane of juxtaglomerular (JG) cells, K is sensed and regulated by K channels (coupled to Cl channels and activated by excess Ca), Na-K-adenosinetriphosphatase, and a KCl/H exchange transporter (regulated by Ca). In JG cell granular membrane, K flux is regulated by K channels and a KCl/H exchange transporter (activated by Ca). H channels and a H pump reside in the granular membrane, which maintain H concentration in the granular matrix at least two orders of magnitude greater than in cytosol. The H pump may also be responsible for maintaining the acidic matrix required for maximal prorenin processing to renin by prohormone convertase for human renin (PCren), the prorenin convertase. These molecules form the core of a chemiosmotic system, which appears to regulate both prorenin processing and renin secretion. Renin secretion and prorenin processing appear to be of more than causal significance in clinical disorders characterized by chemiosmotic imbalance. A critical review of the literature supports the following general conclusions. First, hyperrenin state defines the initial phase in the pathogenesis of heart disease, diabetes mellitus, and hypertension. Second, low-renin syndrome defines the transition-to-establish phase in the pathogenesis of heart disease, diabetes mellitus, and hypertension in which the key feature is renin secretory hyporesponsivity. Third, renin disorders are usually associated with other endocrine disorders (polyendocrinopathies types I, II, and III), suggesting that renin may be an important molecule in the processing of chemiosmotic forces. The key chemiosmotic molecules (K and H) are also important in the processing and export of most (if not all) hormones. Thus, by regulating K and H homeostasis, renin may regulate the endocrine system.</p>
dc.identifier.submissionpathpsych_cmhsr/131
dc.contributor.departmentDepartment of Physiology
dc.contributor.departmentDepartment of Psychiatry
dc.source.pagesF1-12


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