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Authors
Li, MingliDeng, Wei
He, Zongling
Wang, Qiang
Huang, Chaohua
Jiang, Lijun
Gong, Qiyong
Ziedonis, Douglas M.
King, Jean A.
Ma, Xiaohong
Zhang, Nanyin
Li, Tao
Document Type
Journal ArticlePublication Date
2015-05-30Keywords
AdolescentAdult
Brain
Brain Mapping
Female
Humans
Magnetic Resonance Imaging
Male
Nerve Net
Schizophrenia
Young Adult
Functional connectivity
Neural networks
Resting state
Schizophrenia
fMRI
Mental Disorders
Neuroscience and Neurobiology
Psychiatric and Mental Health
Psychiatry
Metadata
Show full item recordAbstract
Dysconnectivity between key brain systems has been hypothesized to underlie the pathophysiology of schizophrenia. The present study examined the pattern of functional dysconnectivity across whole-brain neural networks in 121 first-episode, treatment-naive patients with schizophrenia by using resting-state functional magnetic resonance imaging (rsfMRI). Group independent component analysis (ICA) was first applied to rsfMRI data to extract 90 functional components of the brain. The functional connectivity between these ICA components was then evaluated and compared between the patient and control groups. To examine the functional roles of significantly altered between-component connections in patients, each ICA component was ascribed to one of 10 previously well-defined brain networks/areas. Relative to findings in healthy controls (n=103), 29 altered functional connections including 19 connections with increased connectivity and 10 connections with decreased connectivity in schizophrenia patients were found. Increased connectivity was mainly within the default mode network (DMN) and between the DMN and cognitive networks, whereas decreased connectivity was predominantly associated with sensory networks. Given the key roles of the DMN in internal mental processes and sensory networks in inputs from the external environment, these patterns of altered brain network connectivity could suggest imbalanced neural processing of internal and external information in schizophrenia.Source
Psychiatry Res. 2015 May 30;232(2):145-53. doi: 10.1016/j.pscychresns.2015.03.001. Epub 2015 Mar 11. Link to article on publisher's siteDOI
10.1016/j.pscychresns.2015.03.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45523PubMed ID
25819347Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.pscychresns.2015.03.001