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Choroid plexus blood flow: evidence for dopaminergic influence

dc.contributor.authorTownsend, John B.
dc.contributor.authorZiedonis, Douglas M.
dc.contributor.authorBryan, Robert M.
dc.contributor.authorBrennan, Robert W.
dc.contributor.authorPage, Robert B.
dc.date2022-08-11T08:10:26.000
dc.date.accessioned2022-08-23T17:08:38Z
dc.date.available2022-08-23T17:08:38Z
dc.date.issued1984-01-02
dc.date.submitted2010-08-28
dc.identifier.citationBrain Res. 1984 Jan 2;290(1):165-9.
dc.identifier.issn0006-8993 (Linking)
dc.identifier.pmid6692134
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45625
dc.description.abstractChoroid plexus blood flow was measured in adult female sheep using the radioactive microsphere technique. The response of choroid plexus, renal and cortical blood flow to the infusion of dopamine (11 sheep), haloperidol (7 sheep) and propranolol (6 sheep) were compared. Choroid plexus and renal blood flow significantly increased after dopamine infusion (55% and 49% respectively). Choroid plexus and renal blood flow decreased significantly following haloperidol infusion (-24% and 29% respectively). Cortical blood flow did not significantly change. Propranolol infusion did not significantly change blood flow in these regions. These observations suggest that dopaminergic mechanisms play a role in the regulation of choroid plexus as well as renal blood flow.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=6692134&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/0006-8993(84)90748-0
dc.subjectAnimals
dc.subjectCerebral Cortex
dc.subjectChoroid Plexus
dc.subjectDopamine
dc.subjectFemale
dc.subjectHaloperidol
dc.subjectPropranolol
dc.subjectRegional Blood Flow
dc.subjectRenal Circulation
dc.subjectSheep
dc.subjectPsychiatry
dc.titleChoroid plexus blood flow: evidence for dopaminergic influence
dc.typeJournal Article
dc.source.journaltitleBrain research
dc.source.volume290
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/154
dc.identifier.contextkey1482955
html.description.abstract<p>Choroid plexus blood flow was measured in adult female sheep using the radioactive microsphere technique. The response of choroid plexus, renal and cortical blood flow to the infusion of dopamine (11 sheep), haloperidol (7 sheep) and propranolol (6 sheep) were compared. Choroid plexus and renal blood flow significantly increased after dopamine infusion (55% and 49% respectively). Choroid plexus and renal blood flow decreased significantly following haloperidol infusion (-24% and 29% respectively). Cortical blood flow did not significantly change. Propranolol infusion did not significantly change blood flow in these regions. These observations suggest that dopaminergic mechanisms play a role in the regulation of choroid plexus as well as renal blood flow.</p>
dc.identifier.submissionpathpsych_pp/154
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages165-9


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