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dc.contributor.authorLeal, Josiane
dc.contributor.authorZiedonis, Douglas M.
dc.contributor.authorKosten, Thomas R.
dc.date2022-08-11T08:10:26.000
dc.date.accessioned2022-08-23T17:08:40Z
dc.date.available2022-08-23T17:08:40Z
dc.date.issued1994-03-01
dc.date.submitted2010-08-28
dc.identifier.citationDrug Alcohol Depend. 1994 Mar;35(1):31-5.
dc.identifier.issn0376-8716 (Linking)
dc.identifier.pmid8082553
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45632
dc.description.abstractPharmacotherapy response was compared in 94 cocaine-abusing methadone patients with (n = 75) and without (n = 19) antisocial personality disorder (ASP), in a 12-week, randomized, double-blind trial using desipramine 150 mg daily (n = 30), amantadine 300 mg daily (n = 33), and placebo (n = 31). Retention was lower for the ASP group (ASP 9.6 weeks vs. non-ASP 11.2 weeks). During the first 2 weeks, there was no significant difference in the percentage of cocaine-free urines between the ASP vs. non-ASP patients (9% vs. 18%), but during the last 2 weeks, the non-ASP patients showed a significantly greater percentage of cocaine-free urines (30% vs. 7%). Placebo-treated patients in both groups demonstrated no significant difference in their urine toxicologies comparing the first to the last two weeks of treatment. However, the percentage of cocaine-free urines increased from 15% to 32% in medicated non-ASP patients, but showed no change in medicated ASP patients. Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8082553&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/0376-8716(94)90107-4
dc.subjectAdult
dc.subjectAmantadine
dc.subjectAntisocial Personality Disorder
dc.subject*Cocaine
dc.subjectCombined Modality Therapy
dc.subjectComorbidity
dc.subjectDepressive Disorder
dc.subjectDesipramine
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHeroin Dependence
dc.subjectHumans
dc.subjectMale
dc.subjectMethadone
dc.subjectPatient Dropouts
dc.subjectSubstance Abuse Detection
dc.subjectSubstance-Related Disorders
dc.subjectPsychiatry
dc.titleAntisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence
dc.typeJournal Article
dc.source.journaltitleDrug and alcohol dependence
dc.source.volume35
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/165
dc.identifier.contextkey1482966
html.description.abstract<p>Pharmacotherapy response was compared in 94 cocaine-abusing methadone patients with (n = 75) and without (n = 19) antisocial personality disorder (ASP), in a 12-week, randomized, double-blind trial using desipramine 150 mg daily (n = 30), amantadine 300 mg daily (n = 33), and placebo (n = 31). Retention was lower for the ASP group (ASP 9.6 weeks vs. non-ASP 11.2 weeks). During the first 2 weeks, there was no significant difference in the percentage of cocaine-free urines between the ASP vs. non-ASP patients (9% vs. 18%), but during the last 2 weeks, the non-ASP patients showed a significantly greater percentage of cocaine-free urines (30% vs. 7%). Placebo-treated patients in both groups demonstrated no significant difference in their urine toxicologies comparing the first to the last two weeks of treatment. However, the percentage of cocaine-free urines increased from 15% to 32% in medicated non-ASP patients, but showed no change in medicated ASP patients. Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients.</p>
dc.identifier.submissionpathpsych_pp/165
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages31-5


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