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    D-fenfluramine-induced prolactin responses in postwithdrawal alcoholics and controls

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    Authors
    Farren, Connor K.
    Ziedonis, Douglas M.
    Clare, Anthony W.
    Hammeedi, Faiq A.
    Dinan, Timothy G.
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    1995-12-01
    Keywords
    Adult
    Alcohol Withdrawal Delirium
    Alcoholism
    Fenfluramine
    Genotype
    Humans
    Male
    Middle Aged
    Prolactin
    Receptors, Serotonin
    Reference Values
    Temperance
    Psychiatry
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    Link to Full Text
    http://dx.doi.org/10.1111/j.1530-0277.1995.tb01027.x
    Abstract
    Serum prolactin response to the serotonin agonist D-fenfluramine were measured in 19 DSM-111-R male alcoholics, 2.5 or more weeks postalcohol withdrawal. Prolactin responses were compared with nine healthy nonalcoholic male controls. After an overnight fast, each subject received 30 mg of D-fenfluramine orally, and serial samples of serum prolactin were taken over a 4-hr period. D-fenfluramine caused a significantly attenuated peak delta-prolactin response in the alcoholics relative to the controls (p = 0.05). A repeated-measures ANOVA of delta-prolactin yielded a significant within-subjects effect of time (p < 0.05), a within-subjects effect of group that reached significance (p = 0.05), and a nonsignificant group by time interaction. The delta-prolactin value at time points 60 and 240 min postadministration of the probe was significantly attenuated in the alcoholic group, with p < 0.05. There was also some evidence for a diminished serotonergic response in those alcoholics with a negative family history. The delta-prolactin response did not correlate with subjects' age, duration of alcohol use, duration of abstinence from alcohol, severity of alcohol dependence, or age of onset. Results imply a relative subsensitivity of the serotonin system in postwithdrawal alcoholics, and this may be primarily of the 5-HT2 receptor.
    Source
    Alcohol Clin Exp Res. 1995 Dec;19(6):1578-82.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45633
    PubMed ID
    8749830
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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