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    Psychotic and nonpsychotic depressions: II. Platelet MAO activity, plasma catecholamines, cortisol, and specific symptoms

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    Authors
    Schatzberg, Alan F.
    Rothschild, Anthony J.
    Langlais, Philip J.
    Lerbinger, Jan E.
    Schildkraut, Joseph J.
    Cole, Jonathan O.
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    1987-02-01
    Keywords
    Blood Platelets
    Catecholamines
    *Clinical Enzyme Tests
    Depressive Disorder
    Dexamethasone
    Dopamine
    Epinephrine
    Humans
    Hydrocortisone
    Monoamine Oxidase
    Norepinephrine
    Psychiatry
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    Link to Full Text
    http://dx.doi.org/10.1016/0165-1781(87)90007-2
    Abstract
    Preliminary data are presented on levels of plasma cortisol, dopamine (DA), epinephrine (EPI), and norepinephrine (NE) before and after dexamethasone in 22 depressed patients (of whom 4 were psychotic). Platelet monoamine oxidase (MAO) activity, determined in 19 of the depressed patients, was significantly higher in the 4 psychotic patients than it was in the 15 nonpsychotic patients. Positive correlations were observed before and after dexamethasone among cortisol, DA, EPI, and platelet MAO. After dexamethasone, plasma NE correlated negatively with DA, EPI, and cortisol. The various correlations were due largely to the inclusion of the psychotic depressive subgroup. Data are also presented on the relationships between these biological measures and specific signs and symptoms.
    Source
    Psychiatry Res. 1987 Feb;20(2):155-64.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45730
    PubMed ID
    3575560
    Related Resources
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    UMass Chan Faculty and Researcher Publications

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