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    Differential effects of prenatal and postnatal ACTH or nicotine exposure on 5-HT high affinity uptake in the neonatal rat brain

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    Authors
    King, Jean A.
    Davila-Garcia, Martha
    Azmitia, Efrain C.
    Strand, Fleur L.
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    1991-01-01
    Keywords
    Adrenocorticotropic Hormone
    Animals
    Animals, Newborn
    Aspirin
    Brain
    Brain Stem
    Female
    Nicotine
    Pregnancy
    Prenatal Exposure Delayed Effects
    Rats
    Rats, Inbred Strains
    Serotonin
    Psychiatry
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    Link to Full Text
    http://dx.doi.org/10.1016/0736-5748(91)90048-Q
    Abstract
    These studies were designed to examine the differential effects of prenatal or postnatal administration of ACTH 1-39 and nicotine, on 5-HT high affinity uptake in brainstem and hippocampal synaptosomes. ACTH was administered prenatally (to pregnant dams) and postnatally to the neonates. Postnatal administration of ACTH significantly increased high-affinity 5-HT uptake in the hippocampus and especially the brainstem at both 7 and 21 days after birth. Prenatal ACTH, on the other hand, transiently increased 5-HT uptake in only the brainstem at 7 days, a change that was reversed at 21 days. While the effects of postnatal nicotine administration were essentially the same as those of postnatal ACTH treatment, prenatal nicotine, unlike ACTH, did not alter 5-HT uptake in 7-day-old rats but did reduce uptake in both tissues at 21 days. The observation that postnatal nicotine mimics the effects of postnatal ACTH and that nicotine stimulates ACTH release, suggests that the postnatal effects of nicotine may be exerted through ACTH.
    Source
    Int J Dev Neurosci. 1991;9(3):281-6.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45806
    PubMed ID
    1656708
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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