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    A dual RF resonator system for high-field functional magnetic resonance imaging of small animals

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    Authors
    Ludwig, Reinhold
    Bodgdanov, G.
    King, Jean A.
    Allard, A.
    Ferris, Craig F.
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2004-01-07
    Keywords
    Animals
    Brain
    Brain Mapping
    Electromagnetic Fields
    Electronics
    Electrophysiology
    Magnetic Resonance Imaging
    Magnetics
    Neurophysiology
    Rats
    Reproducibility of Results
    Restraint, Physical
    Sensitivity and Specificity
    Psychiatry
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    Link to Full Text
    http://dx.doi.org/10.1016/j.jneumeth.2003.08.017
    Abstract
    A new apparatus has been developed that integrates an animal restrainer arrangement for small animals with an actively tunable/detunable dual radio-frequency (RF) coil system for in vivo anatomical and functional magnetic resonance imaging of small animals at 4.7 T. The radio-frequency coil features an eight-element microstrip line configuration that, in conjunction with a segmented outer copper shield, forms a transversal electromagnetic (TEM) resonator structure. Matching and active tuning/detuning is achieved through fixed/variable capacitors and a PIN diode for each resonator element. These components along with radio-frequency chokes (RFCs) and blocking capacitors are placed on two printed circuit boards (PCBs) whose copper coated ground planes form the front and back of the volume coil and are therefore an integral part of the resonator structure. The magnetic resonance signal response is received with a dome-shaped single-loop surface coil that can be height-adjustable with respect to the animal's head. The conscious animal is immobilized through a mechanical arrangement that consists of a Plexiglas body tube and a head restrainer. This restrainer has a cylindrical holder with a mouthpiece and position screws to receive and restrain the head of the animal. The apparatus is intended to perform anatomical and functional magnetic resonance imaging in conscious animals such as mice, rats, hamsters, and marmosets. Cranial images acquired from fully conscious rats in a 4.7 T Bruker 40 cm bore animal scanner underscore the feasibility of this approach and bode well to extend this system to the imaging of other animals.
    Source
    J Neurosci Methods. 2004 Jan 30;132(2):125-35.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45821
    PubMed ID
    14706710
    Related Resources
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    UMass Chan Faculty and Researcher Publications

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