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dc.contributor.authorLudwig, Reinhold
dc.contributor.authorBodgdanov, G.
dc.contributor.authorKing, Jean A.
dc.contributor.authorAllard, A.
dc.contributor.authorFerris, Craig F.
dc.date2022-08-11T08:10:27.000
dc.date.accessioned2022-08-23T17:09:26Z
dc.date.available2022-08-23T17:09:26Z
dc.date.issued2004-01-07
dc.date.submitted2010-11-01
dc.identifier.citationJ Neurosci Methods. 2004 Jan 30;132(2):125-35.
dc.identifier.issn0165-0270 (Linking)
dc.identifier.pmid14706710
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45821
dc.description.abstractA new apparatus has been developed that integrates an animal restrainer arrangement for small animals with an actively tunable/detunable dual radio-frequency (RF) coil system for in vivo anatomical and functional magnetic resonance imaging of small animals at 4.7 T. The radio-frequency coil features an eight-element microstrip line configuration that, in conjunction with a segmented outer copper shield, forms a transversal electromagnetic (TEM) resonator structure. Matching and active tuning/detuning is achieved through fixed/variable capacitors and a PIN diode for each resonator element. These components along with radio-frequency chokes (RFCs) and blocking capacitors are placed on two printed circuit boards (PCBs) whose copper coated ground planes form the front and back of the volume coil and are therefore an integral part of the resonator structure. The magnetic resonance signal response is received with a dome-shaped single-loop surface coil that can be height-adjustable with respect to the animal's head. The conscious animal is immobilized through a mechanical arrangement that consists of a Plexiglas body tube and a head restrainer. This restrainer has a cylindrical holder with a mouthpiece and position screws to receive and restrain the head of the animal. The apparatus is intended to perform anatomical and functional magnetic resonance imaging in conscious animals such as mice, rats, hamsters, and marmosets. Cranial images acquired from fully conscious rats in a 4.7 T Bruker 40 cm bore animal scanner underscore the feasibility of this approach and bode well to extend this system to the imaging of other animals.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=14706710&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.jneumeth.2003.08.017
dc.subjectAnimals
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectElectromagnetic Fields
dc.subjectElectronics
dc.subjectElectrophysiology
dc.subjectMagnetic Resonance Imaging
dc.subjectMagnetics
dc.subjectNeurophysiology
dc.subjectRats
dc.subjectReproducibility of Results
dc.subjectRestraint, Physical
dc.subjectSensitivity and Specificity
dc.subjectPsychiatry
dc.titleA dual RF resonator system for high-field functional magnetic resonance imaging of small animals
dc.typeJournal Article
dc.source.journaltitleJournal of neuroscience methods
dc.source.volume132
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/350
dc.identifier.contextkey1625932
html.description.abstract<p>A new apparatus has been developed that integrates an animal restrainer arrangement for small animals with an actively tunable/detunable dual radio-frequency (RF) coil system for in vivo anatomical and functional magnetic resonance imaging of small animals at 4.7 T. The radio-frequency coil features an eight-element microstrip line configuration that, in conjunction with a segmented outer copper shield, forms a transversal electromagnetic (TEM) resonator structure. Matching and active tuning/detuning is achieved through fixed/variable capacitors and a PIN diode for each resonator element. These components along with radio-frequency chokes (RFCs) and blocking capacitors are placed on two printed circuit boards (PCBs) whose copper coated ground planes form the front and back of the volume coil and are therefore an integral part of the resonator structure. The magnetic resonance signal response is received with a dome-shaped single-loop surface coil that can be height-adjustable with respect to the animal's head. The conscious animal is immobilized through a mechanical arrangement that consists of a Plexiglas body tube and a head restrainer. This restrainer has a cylindrical holder with a mouthpiece and position screws to receive and restrain the head of the animal. The apparatus is intended to perform anatomical and functional magnetic resonance imaging in conscious animals such as mice, rats, hamsters, and marmosets. Cranial images acquired from fully conscious rats in a 4.7 T Bruker 40 cm bore animal scanner underscore the feasibility of this approach and bode well to extend this system to the imaging of other animals.</p>
dc.identifier.submissionpathpsych_pp/350
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages125-35


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