An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia
AuthorsFrazier, Jean A.
Gordon, Charles T.
Lenane, Marge C.
Rapoport, Judith L.
UMass Chan AffiliationsDepartment of Psychiatry
Document TypeJournal Article
Psychiatric Status Rating Scales
MetadataShow full item record
AbstractOBJECTIVE: To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial. METHOD: Eleven children meeting DSM-III-R criteria for schizophrenia had a 6-week open trial of clozapine (mean sixth week daily dose 370 mg). Behavioral ratings included the Brief Psychiatric Rating Scale and Children's Global Assessment Scale. RESULTS: More than half showed marked improvement in Brief Psychiatric Rating Scale ratings by 6 weeks of clozapine therapy compared to admission drug rating and compared to a systematic 6-week trial of haloperidol. CONCLUSIONS: This open trial indicates that clozapine may be a promising treatment for children and adolescents with schizophrenia who do not respond well to typical neuroleptics. A double-blind placebo-controlled study is ongoing.
SourceJ Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):658-63. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/45835
Related ResourcesLink to Article in PubMed