An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia
Authors
Frazier, Jean A.Gordon, Charles T.
McKenna, Kathleen
Lenane, Marge C.
Jih, Debbie
Rapoport, Judith L.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
1994-06-01Keywords
AdolescentChild
Clozapine
Double-Blind Method
Female
Haloperidol
Humans
Male
Psychiatric Status Rating Scales
Schizophrenia, Childhood
Psychiatry
Metadata
Show full item recordAbstract
OBJECTIVE: To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial. METHOD: Eleven children meeting DSM-III-R criteria for schizophrenia had a 6-week open trial of clozapine (mean sixth week daily dose 370 mg). Behavioral ratings included the Brief Psychiatric Rating Scale and Children's Global Assessment Scale. RESULTS: More than half showed marked improvement in Brief Psychiatric Rating Scale ratings by 6 weeks of clozapine therapy compared to admission drug rating and compared to a systematic 6-week trial of haloperidol. CONCLUSIONS: This open trial indicates that clozapine may be a promising treatment for children and adolescents with schizophrenia who do not respond well to typical neuroleptics. A double-blind placebo-controlled study is ongoing.Source
J Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):658-63. Link to article on publisher's siteDOI
10.1097/00004583-199406000-00006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45835PubMed ID
8056728Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/00004583-199406000-00006