An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia
AuthorsFrazier, Jean A.
Gordon, Charles T.
Lenane, Marge C.
Rapoport, Judith L.
UMass Chan AffiliationsDepartment of Psychiatry
Psychiatric Status Rating Scales
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AbstractOBJECTIVE: To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial. METHOD: Eleven children meeting DSM-III-R criteria for schizophrenia had a 6-week open trial of clozapine (mean sixth week daily dose 370 mg). Behavioral ratings included the Brief Psychiatric Rating Scale and Children's Global Assessment Scale. RESULTS: More than half showed marked improvement in Brief Psychiatric Rating Scale ratings by 6 weeks of clozapine therapy compared to admission drug rating and compared to a systematic 6-week trial of haloperidol. CONCLUSIONS: This open trial indicates that clozapine may be a promising treatment for children and adolescents with schizophrenia who do not respond well to typical neuroleptics. A double-blind placebo-controlled study is ongoing.
SourceJ Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):658-63. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/45835
Related ResourcesLink to Article in PubMed