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    An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia

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    Authors
    Frazier, Jean A.
    Gordon, Charles T.
    McKenna, Kathleen
    Lenane, Marge C.
    Jih, Debbie
    Rapoport, Judith L.
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    1994-06-01
    Keywords
    Adolescent
    Child
    Clozapine
    Double-Blind Method
    Female
    Haloperidol
    Humans
    Male
    Psychiatric Status Rating Scales
    Schizophrenia, Childhood
    Psychiatry
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    Link to Full Text
    http://dx.doi.org/10.1097/00004583-199406000-00006
    Abstract
    OBJECTIVE: To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial. METHOD: Eleven children meeting DSM-III-R criteria for schizophrenia had a 6-week open trial of clozapine (mean sixth week daily dose 370 mg). Behavioral ratings included the Brief Psychiatric Rating Scale and Children's Global Assessment Scale. RESULTS: More than half showed marked improvement in Brief Psychiatric Rating Scale ratings by 6 weeks of clozapine therapy compared to admission drug rating and compared to a systematic 6-week trial of haloperidol. CONCLUSIONS: This open trial indicates that clozapine may be a promising treatment for children and adolescents with schizophrenia who do not respond well to typical neuroleptics. A double-blind placebo-controlled study is ongoing.
    Source
    J Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):658-63. Link to article on publisher's site
    DOI
    10.1097/00004583-199406000-00006
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45835
    PubMed ID
    8056728
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1097/00004583-199406000-00006
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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