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dc.contributor.authorFrazier, Jean A.
dc.contributor.authorGiedd, Jay N.
dc.contributor.authorHamburger, Susan D.
dc.contributor.authorAlbus, K. E.
dc.contributor.authorKaysen, Debra
dc.contributor.authorVaituzis, A. Catherine
dc.contributor.authorRajapakse, Jagath C.
dc.contributor.authorLenane, Marge C.
dc.contributor.authorMcKenna, Kathleen
dc.contributor.authorJacobsen, Leslie K.
dc.contributor.authorGordon, Charles T.
dc.contributor.authorBreier, Alan
dc.contributor.authorRapoport, Judith L.
dc.date2022-08-11T08:10:27.000
dc.date.accessioned2022-08-23T17:09:30Z
dc.date.available2022-08-23T17:09:30Z
dc.date.issued1996-07-01
dc.date.submitted2011-02-10
dc.identifier.citationArch Gen Psychiatry. 1996 Jul;53(7):617-24.
dc.identifier.issn0003-990X (Linking)
dc.identifier.pmid8660128
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45839
dc.description.abstractBACKGROUND: Early-onset schizophrenia (first psychotic symptoms by age 12 years) has been the subject of a small number of studies, and its biological continuity with later-onset disorder has not been established. In this study quantitative anatomic brain magnetic resonance images of children and adolescents with early-onset schizophrenia were compared with those of matched controls. Brain abnormalities in childhood-onset schizophrenia were examined in relation to those reported for later-onset schizophrenics. METHODS: Anatomic brain magnetic resonance imaging scans were obtained for 21 patients (mean +/- SD age, 14.6 +/- 2.1 years; range, 10 to 18 years) with childhood-onset schizophrenia (13 males, eight females) and 33 age-, sex-, height-, and weight-matched normal controls. Quantitative measurements were obtained for the cerebrum, anterior frontal region, lateral ventricles, thalamus, caudate, putamen, and globus pallidus. RESULTS: Total cerebral volume and midsagittal thalamic area were smaller in the patients (analysis of variance, P = .002, and analysis of covariance, P = .03, respectively); the caudate, putamen, and globus pallidus were larger in the patients (analysis of covariance, P = .05, P = .007, and P < .001, respectively); and the lateral ventricles tended to be larger in the patients (analysis of covariance, P = .06). Globus pallidus enlargement correlated with neuroleptic exposure and with age of onset of psychosis. The magnitude of abnormalities compared with controls was similar to that reported in adult studies, although there was a trend toward relatively smaller cerebral volumes for the childhood-onset group compared with controls. CONCLUSION: Brain anatomic abnormalities in childhood-onset schizophrenia are similar to those reported for adult populations, indicating overall continuity between these rare childhood cases and the adult schizophrenia populations.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8660128&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://archpsyc.ama-assn.org/cgi/reprint/53/7/617
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge of Onset
dc.subjectBrain
dc.subjectCaudate Nucleus
dc.subjectCerebral Ventricles
dc.subjectChild
dc.subjectGlobus Pallidus
dc.subjectHumans
dc.subject*Magnetic Resonance Imaging
dc.subjectPutamen
dc.subjectSchizophrenia, Childhood
dc.subjectThalamus
dc.subjectPsychiatry
dc.titleBrain anatomic magnetic resonance imaging in childhood-onset schizophrenia
dc.typeJournal Article
dc.source.journaltitleArchives of general psychiatry
dc.source.volume53
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/369
dc.identifier.contextkey1775286
html.description.abstract<p>BACKGROUND: Early-onset schizophrenia (first psychotic symptoms by age 12 years) has been the subject of a small number of studies, and its biological continuity with later-onset disorder has not been established. In this study quantitative anatomic brain magnetic resonance images of children and adolescents with early-onset schizophrenia were compared with those of matched controls. Brain abnormalities in childhood-onset schizophrenia were examined in relation to those reported for later-onset schizophrenics.</p> <p>METHODS: Anatomic brain magnetic resonance imaging scans were obtained for 21 patients (mean +/- SD age, 14.6 +/- 2.1 years; range, 10 to 18 years) with childhood-onset schizophrenia (13 males, eight females) and 33 age-, sex-, height-, and weight-matched normal controls. Quantitative measurements were obtained for the cerebrum, anterior frontal region, lateral ventricles, thalamus, caudate, putamen, and globus pallidus.</p> <p>RESULTS: Total cerebral volume and midsagittal thalamic area were smaller in the patients (analysis of variance, P = .002, and analysis of covariance, P = .03, respectively); the caudate, putamen, and globus pallidus were larger in the patients (analysis of covariance, P = .05, P = .007, and P < .001, respectively); and the lateral ventricles tended to be larger in the patients (analysis of covariance, P = .06). Globus pallidus enlargement correlated with neuroleptic exposure and with age of onset of psychosis. The magnitude of abnormalities compared with controls was similar to that reported in adult studies, although there was a trend toward relatively smaller cerebral volumes for the childhood-onset group compared with controls.</p> <p>CONCLUSION: Brain anatomic abnormalities in childhood-onset schizophrenia are similar to those reported for adult populations, indicating overall continuity between these rare childhood cases and the adult schizophrenia populations.</p>
dc.identifier.submissionpathpsych_pp/369
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages617-24


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