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dc.contributor.authorJacobsen, Leslie K.
dc.contributor.authorHong, Walter L.
dc.contributor.authorHommer, Daniel W.
dc.contributor.authorHamburger, Susan D.
dc.contributor.authorCastellanos, F. Xavier
dc.contributor.authorFrazier, Jean A.
dc.contributor.authorGiedd, Jay N.
dc.contributor.authorGordon, Charles T.
dc.contributor.authorKarp, Barbara I.
dc.contributor.authorMcKenna, Kathleen
dc.contributor.authorRapoport, Judith L.
dc.date2022-08-11T08:10:27.000
dc.date.accessioned2022-08-23T17:09:31Z
dc.date.available2022-08-23T17:09:31Z
dc.date.issued1996-12-01
dc.date.submitted2011-02-10
dc.identifier.citationBiol Psychiatry. 1996 Dec 1;40(11):1144-54. <a href="http://dx.doi.org/10.1016/S0006-3223(95)00630-3">Link to article on publisher's site</a>
dc.identifier.issn0006-3223 (Linking)
dc.identifier.doi10.1016/S0006-3223(95)00630-3
dc.identifier.pmid8931918
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45841
dc.description.abstractAbnormalities of the smooth pursuit eye movements of adults with schizophrenia have been well described. We examined smooth pursuit eye movements in schizophrenic children, contrasting them with normal and attention-deficit hyperactivity disorder (ADHD) subjects, to determine whether there is continuity of eye movement dysfunction between childhood- and adult-onset forms of schizophrenia. Seventeen schizophrenic children with onset of illness by age 12, 18 ADHD children, and 22 normal children were studied while engaged in a smooth pursuit eye tracking task. Eye tracking variables were compared across the three groups. Schizophrenic children exhibited significantly greater smooth pursuit impairments than either normal or ADHD subjects. Within the schizophrenic group, there were no significant relationships between eye tracking variables and clinical variables, or ventricular/brain ratio. Childhood-onset schizophrenia is associated with a similar pattern of smooth pursuit abnormalities to that seen in later-onset schizophrenia.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8931918&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/S0006-3223(95)00630-3
dc.subjectAdolescent
dc.subjectAttention Deficit Disorder with Hyperactivity
dc.subjectBrain
dc.subjectCerebral Ventricles
dc.subjectChild
dc.subjectCognition
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPsychiatric Status Rating Scales
dc.subjectPsychomotor Performance
dc.subjectPursuit, Smooth
dc.subjectSchizophrenia, Childhood
dc.subjectSchizophrenic Psychology
dc.subjectPsychiatry
dc.titleSmooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls
dc.typeJournal Article
dc.source.journaltitleBiological psychiatry
dc.source.volume40
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/370
dc.identifier.contextkey1775288
html.description.abstract<p>Abnormalities of the smooth pursuit eye movements of adults with schizophrenia have been well described. We examined smooth pursuit eye movements in schizophrenic children, contrasting them with normal and attention-deficit hyperactivity disorder (ADHD) subjects, to determine whether there is continuity of eye movement dysfunction between childhood- and adult-onset forms of schizophrenia. Seventeen schizophrenic children with onset of illness by age 12, 18 ADHD children, and 22 normal children were studied while engaged in a smooth pursuit eye tracking task. Eye tracking variables were compared across the three groups. Schizophrenic children exhibited significantly greater smooth pursuit impairments than either normal or ADHD subjects. Within the schizophrenic group, there were no significant relationships between eye tracking variables and clinical variables, or ventricular/brain ratio. Childhood-onset schizophrenia is associated with a similar pattern of smooth pursuit abnormalities to that seen in later-onset schizophrenia.</p>
dc.identifier.submissionpathpsych_pp/370
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages1144-54


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