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dc.contributor.authorDeFosse, Lies
dc.contributor.authorHodge, Steven M
dc.contributor.authorMakris, Nikos
dc.contributor.authorKennedy, David N.
dc.contributor.authorCaviness, Verne S. Jr.
dc.contributor.authorMcGrath, Lauren
dc.contributor.authorSteele, Shelley
dc.contributor.authorZiegler, David A.
dc.contributor.authorHerbert, Martha R.
dc.contributor.authorFrazier, Jean A.
dc.contributor.authorTager-Flusberg, Helen
dc.contributor.authorHarris, Gordon J.
dc.date2022-08-11T08:10:27.000
dc.date.accessioned2022-08-23T17:09:37Z
dc.date.available2022-08-23T17:09:37Z
dc.date.issued2004-12-13
dc.date.submitted2011-02-10
dc.identifier.citationAnn Neurol. 2004 Dec;56(6):757-66. <a href="http://dx.doi.org/10.1002/ana.20275">Link to article on publisher's site</a>
dc.identifier.issn0364-5134 (Linking)
dc.identifier.doi10.1002/ana.20275
dc.identifier.pmid15478219
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45864
dc.description.abstractLanguage deficits are among the core impairments of autism. We previously reported asymmetry reversal of frontal language cortex in boys with autism. Specific language impairment (SLI) and autism share similar language deficits and may share genetic links. This study evaluated asymmetry of frontal language cortex in a new, independent sample of right-handed boys, including a new sample of boys with autism and a group of boys with SLI. The boys with autism were divided into those with language impairment (ALI) and those with normal language ability (ALN). Subjects (right-handed, aged 6.2-13.4 years) included 22 boys with autism (16 ALI and 6 ALN), 9 boys with a history of or present SLI, and 11 normal controls. MRI brain scans were segmented into grey and white matter; then the cerebral cortex was parcellated into 48 gyral-based divisions per hemisphere. Group differences in volumetric asymmetry were predicted a priori in language-related regions in inferior lateral frontal (Broca's area) and posterior superior temporal cortex. Language impaired boys with autism and SLI both had significant reversal of asymmetry in frontal language-related cortex; larger on the right side in both groups of language impaired boys and larger on the left in both unimpaired language groups, strengthening a phenotypic link between ALI and SLI. Thus, we replicated the observation of reversed asymmetry in frontal language cortex reported previously in an independent autism sample, and observed similar reversal in boys with SLI, further strengthening a phenotypic link between SLI and a subgroup of autism. Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15478219&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/ana.20275
dc.subjectAdolescent
dc.subjectAnalysis of Variance
dc.subjectAutistic Disorder
dc.subjectCerebral Cortex
dc.subjectChild
dc.subjectFrontal Lobe
dc.subjectHumans
dc.subjectLanguage Disorders
dc.subjectLanguage Tests
dc.subjectMale
dc.subjectPsychiatry
dc.titleLanguage-association cortex asymmetry in autism and specific language impairment
dc.typeJournal Article
dc.source.journaltitleAnnals of neurology
dc.source.volume56
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/393
dc.identifier.contextkey1775327
html.description.abstract<p>Language deficits are among the core impairments of autism. We previously reported asymmetry reversal of frontal language cortex in boys with autism. Specific language impairment (SLI) and autism share similar language deficits and may share genetic links. This study evaluated asymmetry of frontal language cortex in a new, independent sample of right-handed boys, including a new sample of boys with autism and a group of boys with SLI. The boys with autism were divided into those with language impairment (ALI) and those with normal language ability (ALN). Subjects (right-handed, aged 6.2-13.4 years) included 22 boys with autism (16 ALI and 6 ALN), 9 boys with a history of or present SLI, and 11 normal controls. MRI brain scans were segmented into grey and white matter; then the cerebral cortex was parcellated into 48 gyral-based divisions per hemisphere. Group differences in volumetric asymmetry were predicted a priori in language-related regions in inferior lateral frontal (Broca's area) and posterior superior temporal cortex. Language impaired boys with autism and SLI both had significant reversal of asymmetry in frontal language-related cortex; larger on the right side in both groups of language impaired boys and larger on the left in both unimpaired language groups, strengthening a phenotypic link between ALI and SLI. Thus, we replicated the observation of reversed asymmetry in frontal language cortex reported previously in an independent autism sample, and observed similar reversal in boys with SLI, further strengthening a phenotypic link between SLI and a subgroup of autism. Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis.</p>
dc.identifier.submissionpathpsych_pp/393
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages757-66


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