Risperidone-induced psychosis and depression in a child with a mitochondrial disorder
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2005-06-12Keywords
AdolescentDepressive Disorder
Epilepsy, Tonic-Clonic
Female
Humans
Mitochondrial Diseases
Mood Disorders
Psychoses, Substance-Induced
Risperidone
Psychiatry
Metadata
Show full item recordAbstract
OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone. DATA: A 16-year-old girl was treated with risperidone for mood lability and impulsivity at a community hospital. Within days, she developed paranoid ideation, profound psychomotor retardation, increased depression, and fatigue. She was transferred to an inpatient psychiatric hospital, where she was taken off risperidone. Within 48 hours after discontinuation of the medication, she had complete resolution of psychotic symptoms, fatigue, and psychomotor retardation, and her depression improved. CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent. These findings are consistent with recent in vitro literature, which implicate a series of neuroleptic medications with mitochondrial dysfunction. Furthermore, the authors provide diagnostic and treatment options that are available for mitochondrial disorders, which are of interest to child psychiatrists due to the central nervous system manifestations of these disorders.Source
J Child Adolesc Psychopharmacol. 2005 Jun;15(3):520-5. Link to article on publisher's siteDOI
10.1089/cap.2005.15.520Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45865PubMed ID
16092915Related Resources
Link to Article in PubMedRights
This is a copy of an article published in the Journal of Child and Adolescent Psychopharmacology. © 2005 Mary Ann Liebert, Inc.ae974a485f413a2113503eed53cd6c53
10.1089/cap.2005.15.520