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dc.contributor.authorRothschild, Anthony J.
dc.contributor.authorSamson, Jacqueline A.
dc.contributor.authorBond, Thomas C.
dc.contributor.authorLuciana, Monica M.
dc.contributor.authorSchildkraut, Joseph J.
dc.contributor.authorSchatzberg, Alan F.
dc.date2022-08-11T08:10:27.000
dc.date.accessioned2022-08-23T17:09:39Z
dc.date.available2022-08-23T17:09:39Z
dc.date.issued1993-09-15
dc.date.submitted2010-05-05
dc.identifier.citationBiol Psychiatry. 1993 Sep 15;34(6):392-400.
dc.identifier.issn0006-3223 (Linking)
dc.identifier.pmid8218607
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45871
dc.description.abstractThe relationships of longitudinal biological measures to longer-term outcome in depressed patients have not been well explored. This study was designed to investigate whether in a sample of depressed patients: (a) symptomatic and functional outcome at 1 year was significantly different in psychotic major depressed (PMD) patients as compared with nonpsychotic major depressed (NPMD) patients and (b) high urinary or plasma cortisol levels at baseline or 1 year were associated with poorer outcomes at 1 year. Forty-two depressed patients (9 psychotic, 33 nonpsychotic) were evaluated at baseline and at 1 year using a battery of clinical ratings and measures of cortisol. A group of normal, healthy control subjects were similarly evaluated at baseline. At 1-year follow-up, PMD patients did not differ from NPMD patients in their Hamilton Depression Rating Scale (HDRS) and Brief Psychiatric Rating Scale scores (BPRS), but PMD patients demonstrated significantly poorer social and occupational functioning. Significant correlations were observed (n = 18) between higher levels of urinary and plasma cortisol at 1 year and poorer social and occupational functioning at 1 year, independent of the degree of residual depression. In contrast, baseline measures of urinary and plasma cortisol did not predict social and occupational functioning at 1 year.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8218607&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/0006-3223(93)90184-F
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnalysis of Variance
dc.subjectDepressive Disorder
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrocortisone
dc.subjectHypothalamo-Hypophyseal System
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPituitary-Adrenal System
dc.subjectPrognosis
dc.subjectTime Factors
dc.subjectPsychiatry
dc.titleHypothalamic-pituitary-adrenal axis activity and 1-year outcome in depression
dc.typeJournal Article
dc.source.journaltitleBiological psychiatry
dc.source.volume34
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/40
dc.identifier.contextkey1299387
html.description.abstract<p>The relationships of longitudinal biological measures to longer-term outcome in depressed patients have not been well explored. This study was designed to investigate whether in a sample of depressed patients: (a) symptomatic and functional outcome at 1 year was significantly different in psychotic major depressed (PMD) patients as compared with nonpsychotic major depressed (NPMD) patients and (b) high urinary or plasma cortisol levels at baseline or 1 year were associated with poorer outcomes at 1 year. Forty-two depressed patients (9 psychotic, 33 nonpsychotic) were evaluated at baseline and at 1 year using a battery of clinical ratings and measures of cortisol. A group of normal, healthy control subjects were similarly evaluated at baseline. At 1-year follow-up, PMD patients did not differ from NPMD patients in their Hamilton Depression Rating Scale (HDRS) and Brief Psychiatric Rating Scale scores (BPRS), but PMD patients demonstrated significantly poorer social and occupational functioning. Significant correlations were observed (n = 18) between higher levels of urinary and plasma cortisol at 1 year and poorer social and occupational functioning at 1 year, independent of the degree of residual depression. In contrast, baseline measures of urinary and plasma cortisol did not predict social and occupational functioning at 1 year.</p>
dc.identifier.submissionpathpsych_pp/40
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages392-400


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