Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex
Authors
Moore, Constance M.Frazier, Jean A.
Glod, Carol A.
Breeze, Janis L.
Dieterich, Megan E.
Finn, Chelsea T.
Frederick, Blaise Deb
Renshaw, Perry F.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2007-04-11Keywords
AdolescentAdult
Analysis of Variance
Bipolar Disorder
Child
Child, Preschool
Female
Glutamic Acid
Glutamine
Gyrus Cinguli
Humans
Magnetic Resonance Spectroscopy
Male
Neuroglia
Occipital Lobe
Protons
Psychotropic Drugs
Psychiatry
Metadata
Show full item recordAbstract
OBJECTIVE: The purpose of this study was to use proton magnetic resonance spectroscopy, at 4.0 T, to explore the glutamine and glutamate levels in the anterior cingulate cortex of children and adolescents with bipolar disorder (BPD; medicated and unmedicated) and healthy comparison subjects (HCSs). We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD. METHOD: Spectra were acquired from the anterior cingulate cortex in 22 children and adolescents with DSM-IV-TR BPD, type 1 (13 female: age 12.6 +/- 4.4 years: 7 of the subjects with BPD were unmedicated at the time of the scan) and 10 HCSs (7 female: age 12.3 +/- 2.5 years). RESULTS: Unmedicated subjects with BPD had significantly lower glutamine levels than HCSs or medicated subjects with BPD. There were no differences in glutamate levels between the three groups. CONCLUSIONS: These results are consistent with there being an abnormality in anterior cingulate cortex glia in untreated children and adolescents with BPD. The results of this pilot study may be important in helping us better understand the pathophysiology of child and adolescent BPD. In addition, this observation may help to develop better and more targeted treatments, in particular those affecting the metabolism of glutamine, perhaps by regulation of glutamine synthetase activity.Source
J Am Acad Child Adolesc Psychiatry. 2007 Apr;46(4):524-34. Link to article on publisher's siteDOI
10.1097/chi.0b013e31802f5f2cPermanent Link to this Item
http://hdl.handle.net/20.500.14038/45879PubMed ID
17420688Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/chi.0b013e31802f5f2c