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    Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia

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    Authors
    Frazier, Jean A.
    Hodge, Steven M.
    Breeze, Janis L.
    Giuliano, Anthony J.
    Terry, Janine E.
    Moore, Constance M.
    Kennedy, David N.
    Lopez-Larson, Melissa P.
    Caviness, Verne S. Jr.
    Seidman, Larry J.
    Zablotsky, Benjamin
    Makris, Nikos
    Show allShow less
    UMass Chan Affiliations
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2008-01-01
    Keywords
    Adolescent
    Age of Onset
    Amygdala
    Bipolar Disorder
    Child
    Female
    Hippocampus
    Humans
    Limbic System
    *Magnetic Resonance Imaging
    Male
    Schizophrenia, Childhood
    Severity of Illness Index
    Sex Factors
    mood disorders
    psychosis
    brain imaging technique
    child psychiatry
    Mental Disorders
    Nervous System
    Neuroscience and Neurobiology
    Psychiatry
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632388/
    Abstract
    OBJECTIVE: The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex. METHODS: Thirty-five youths with DSM-IV BPD without psychosis, 19 with BPD with psychosis, 20 with SZ, and 29 healthy controls (HC), similar in age (6-17 years) and sex, underwent structured and clinical interviews, neurological examination, and cognitive testing. Structural magnetic resonance images (MRIs) were acquired on a 1.5 Tesla, General Electric Signa Scanner. Differences in subcortical brain volumes, including the amygdala and hippocampus, were evaluated using two-way (diagnosis, sex) univariate analyses covarying for total cerebral volume and age. RESULTS: Youth with SZ and BPD showed no differences in amygdala and hippocampal volumes. However, boys with SZ had smallest left amygdala and girls with BPD had the smallest left hippocampal volumes. In exploratory analyses, SZ showed reduced thalamic volumes bilaterally and both BPD groups had larger right nucleus accumbens (NA) volumes relative to HC. CONCLUSION: There were no limbic volumetric differences between BPD and SZ. However, there were diagnosis-by-sex interactions in the amygdala and hippocampus, structures that are rich in sex hormone receptors. In addition, smaller thalamus was associated with SZ while larger right NA volumes were most related to BPD. This study underscores the importance of assessing diagnostic effects and sex effects on the brain in future studies and provides evidence that boys and girls with SZ and BPD may have differential patterns of neuropathology associated with disease expression.
    Source
    Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophr Bull. 2008 Jan;34(1):37-46. Epub 2007 Nov 13. Erratum in: Schizophr Bull. 2009 Nov;35(6):1197. PubMed PMID: 18003631; PubMed Central PMCID: PMC2632388. Link to article on publisher's site
    DOI
    10.1093/schbul/sbm120
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/45886
    PubMed ID
    18003631
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/schbul/sbm120
    Scopus Count
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