Metformin for weight control in pediatric patients on atypical antipsychotic medication
UMass Chan AffiliationsDepartment of Psychiatry
Document TypeJournal Article
Body Mass Index
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AbstractOBJECTIVE: Metformin was assessed as an interventional medication for weight gain in children and adolescents taking atypical antipsychotic agents. METHOD: A 12-week open-label trial was conducted to evaluate metformin's effectiveness and safety for weight management. Eleven subjects, ages 10-18 years, participated in the study. Each subject received metformin orally up to 2000 mg/day. Primary outcome measures included weight, body mass index (BMI), and waist circumference. Secondary outcome measures included serum glucose, insulin, and fasting lipid profile. Changes in weight, BMI, waist, and metabolic profile were obtained by using repeated measures of covariance. RESULTS: The mean reduction in weight, waist, BMI, serum glucose, and serum insulin was not statistically significant. However, 5 out of 11 patients lost weight (mean, -2.82 kg +/- 7.25), and overall the sample did not continue to gain weight. There was a significant decrease in triglyceride levels. Metformin was fairly well tolerated. CONCLUSION: Preliminary data suggests that metformin may safely and effectively improve the triglyceride profile. However, contrary to study hypotheses, weight, waist, and BMI reduction were not statistically significant. Future double-blind studies with larger sample sizes and of longer duration are warranted to assess more fully the safety and efficacy of this intervention.
SourceJ Child Adolesc Psychopharmacol. 2009 Jun;19(3):275-9. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/45892
Related ResourcesLink to Article in PubMed
RightsThis is a copy of an article published in the Journal of Child and Adolescent Psychopharmacology. © 2009 Mary Ann Liebert, Inc.