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Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder

dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorBiederman, Joseph
dc.contributor.authorWeiffenbach, Barbara
dc.contributor.authorKeith, Tim
dc.contributor.authorChu, Monica P.
dc.contributor.authorWeaver, Alix
dc.contributor.authorSpencer, Thomas J.
dc.contributor.authorWilens, Timothy E.
dc.contributor.authorFrazier, Jean A.
dc.contributor.authorCleves, Mario
dc.contributor.authorSakai, Jun
dc.date2022-08-11T08:10:27.000
dc.date.accessioned2022-08-23T17:09:49Z
dc.date.available2022-08-23T17:09:49Z
dc.date.issued1999-05-18
dc.date.submitted2011-02-11
dc.identifier.citationAm J Psychiatry. 1999 May;156(5):768-70.
dc.identifier.issn0002-953X (Linking)
dc.identifier.pmid10327912
dc.identifier.urihttp://hdl.handle.net/20.500.14038/45907
dc.description.abstractOBJECTIVE: Family, twin, and adoption studies show attention deficit hyperactivity disorder (ADHD) to have a substantial genetic component, and some studies have reported an association between ADHD and the dopamine D4 (DRD4) gene. METHOD: The authors recruited 27 triads that comprised an ADHD adult, his or her spouse, and their ADHD child. These triads were assessed for ADHD, and their DNA was genotyped for DRD4 alleles. RESULTS: A multiallelic transmission disequilibrium test suggested an association between ADHD and the DRD4 7-repeat allele. Among family members, the number of 7-repeat alleles predicted the diagnosis of ADHD. CONCLUSIONS: Prior reports of an association between ADHD and DRD4 generalize to families recruited through clinically referred ADHD adults. However, because there are some conflicting studies, further work is needed to clarify the role of DRD4 in the etiology of the disorder.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10327912&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://ajp.psychiatryonline.org/cgi/reprint/156/5/768
dc.subjectAdult
dc.subjectAlleles
dc.subjectAttention Deficit Disorder with Hyperactivity
dc.subjectChild
dc.subjectFemale
dc.subjectGenetic Markers
dc.subjectGenetic Variation
dc.subjectGenotype
dc.subjectHumans
dc.subjectLinkage Disequilibrium
dc.subjectMale
dc.subjectMultigene Family
dc.subjectPolymorphism, Genetic
dc.subjectReceptors, Dopamine
dc.subject*Tandem Repeat Sequences
dc.subjectPsychiatry
dc.titleDopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder
dc.typeJournal Article
dc.source.journaltitleThe American journal of psychiatry
dc.source.volume156
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/psych_pp/433
dc.identifier.contextkey1779637
html.description.abstract<p>OBJECTIVE: Family, twin, and adoption studies show attention deficit hyperactivity disorder (ADHD) to have a substantial genetic component, and some studies have reported an association between ADHD and the dopamine D4 (DRD4) gene.</p> <p>METHOD: The authors recruited 27 triads that comprised an ADHD adult, his or her spouse, and their ADHD child. These triads were assessed for ADHD, and their DNA was genotyped for DRD4 alleles.</p> <p>RESULTS: A multiallelic transmission disequilibrium test suggested an association between ADHD and the DRD4 7-repeat allele. Among family members, the number of 7-repeat alleles predicted the diagnosis of ADHD.</p> <p>CONCLUSIONS: Prior reports of an association between ADHD and DRD4 generalize to families recruited through clinically referred ADHD adults. However, because there are some conflicting studies, further work is needed to clarify the role of DRD4 in the etiology of the disorder.</p>
dc.identifier.submissionpathpsych_pp/433
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages768-70


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